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Zoladex (goserelin)

Indications

• Zoladex is used to treat prostate cancer by reducing the amount of testosterone in your body.
• It helps manage breast cancer in pre- and perimenopausal women by lowering estrogen levels.
• Zoladex is used to treat endometriosis by reducing hormone levels that cause the condition.
• It helps thin the lining of the uterus before endometrial ablation.
• Zoladex is used to manage uterine fibroids by reducing hormone levels that cause growth.

Dosage and Administration

• Always use Zoladex exactly as your doctor has instructed.
• Ensure the injection is administered by a healthcare professional.
• Confirm the injection site is your lower abdomen, as directed.
• Keep all your scheduled appointments for regular injections.
• Inform your healthcare provider about any other medications or supplements you are taking.
• Do not administer Zoladex yourself unless trained by a healthcare professional.
• Avoid missing doses; keep to your injection schedule strictly.
• Do not use Zoladex if you are allergic to goserelin or any other ingredients in the syringe.
• Do not use the syringe if it appears damaged or tampered with.
• Avoid using Zoladex if you are pregnant or planning to become pregnant.

Mechanism of Action

Goserelin, the active ingredient in Zoladex, works by overstimulating the body’s production of certain hormones, initially causing a temporary increase in hormone levels. However, with continued treatment, it significantly reduces the levels of these hormones. In men, it reduces testosterone, and in women, it reduces estrogen. This reduction helps slow or stop the growth of hormone-sensitive tumors and conditions.

Contraindications

• Do not use Zoladex if you are allergic to goserelin or any components of the syringe.
• Avoid Zoladex if you are pregnant, planning to become pregnant, or breastfeeding.
• Do not use Zoladex if you have undiagnosed abnormal vaginal bleeding.
• Avoid using Zoladex if you have a history of severe osteoporosis without consulting your doctor.
• Inform your doctor if you have a history of heart disease or diabetes before starting Zoladex.

Side Effects

Common Side Effects

• Hot flashes
• Sweating
• Decreased libido
• Vaginal dryness or discomfort
• Mood changes
• Injection site reactions

Serious Side Effects

• Severe allergic reactions, such as difficulty breathing or swelling of the face and throat
• Bone pain or fractures
• Severe mood changes or depression
• Symptoms of high blood sugar, such as increased thirst or frequent urination
• Heart problems, including palpitations or chest pain
• Yellowing of the skin or eyes (jaundice)

Precautions

• Regularly monitor bone density if you are at risk for osteoporosis.
• Inform your doctor if you have any history of cardiovascular disease.
• Use effective contraception if you are of childbearing age and sexually active.
• Report any severe mood changes or signs of depression to your healthcare provider.
• Monitor for symptoms of high blood sugar if you have diabetes.

Storage Instructions

• Store the Zoladex syringe at room temperature, below 25°C (77°F).
• Keep the syringe in its original packaging to protect it from light and moisture.
• Keep out of reach of children.
• Do not use the syringe if it has expired or if the packaging is damaged.
• Dispose of the syringe safely and properly after use, following your healthcare provider’s instructions.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/019726s059,020578s037lbl.pdf