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Dosage: 5mg
Quantity: 56
Price: $780.00
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Dosage: 5mg
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Price: $1550.00
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Dosage: 10mg
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Price: $2601.00

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Formulation : Tablet
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Tofacitinib
Dosage: 5mg
Quantity: 60
Price: $360.00

Xeljanz (tofacitinib)

Indications

Xeljanz tablets are prescribed for several autoimmune conditions. Indications include:

  • Rheumatoid Arthritis (RA): Used to reduce symptoms and slow the progression of moderate to severe RA in adults.
  • Psoriatic Arthritis (PsA): Helps to relieve symptoms and improve physical function in adults with active PsA.
  • Ulcerative Colitis (UC): Indicated for adults with moderately to severely active UC to induce and maintain remission.
  • Polyarticular Course Juvenile Idiopathic Arthritis (pcJIA): Prescribed for children 2 years and older with active pcJIA.

Ingredients

  • Active Ingredient: Tofacitinib
  • Inactive Ingredients: Microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, hydroxypropyl cellulose, titanium dioxide, polyethylene glycol, red iron oxide, and black iron oxide.

Dosage and Administration

  • Take Xeljanz tablets exactly as prescribed by your healthcare provider.
  • Swallow the tablets whole; do not crush, chew, or break them.
  • Take with or without food, at the same time each day to maintain consistent levels in your body. If a dose is missed, take it as soon as you remember unless it is almost time for your next dose.
  • Regularly monitor your blood tests as recommended by your doctor to check for side effects and adjust dosage if needed.
  • Do not take more than the prescribed dose to avoid the risk of severe side effects.
  • Avoid taking Xeljanz if you have a severe infection, as it can weaken your immune system further.
  • Avoid live vaccines while taking Xeljanz, as it can increase the risk of infections.
  • Do not stop taking the medication suddenly without consulting your doctor, as it may cause a flare-up of your condition.

Mechanism of Action

Tofacitinib is a Janus kinase (JAK) inhibitor that works by blocking the activity of certain enzymes involved in the inflammatory process. By inhibiting these enzymes, Xeljanz reduces inflammation and modulates the immune response, helping to alleviate symptoms of autoimmune diseases.

Contraindications

  • Do not use Xeljanz if you are allergic to tofacitinib or any of its ingredients.
  • Avoid use if you have a serious infection, such as sepsis or tuberculosis.
  • Not recommended for individuals with severe liver impairment.
  • Inform your doctor if you have a history of blood clots or are at risk for cardiovascular events.
  • Do not use if you are pregnant or planning to become pregnant without consulting your healthcare provider.

Side Effects

Common Side Effects

  • Headache
  • Diarrhea
  • Nasopharyngitis (common cold)
  • High blood pressure
  • Upper respiratory tract infection

Serious Side Effects

  • Severe infections (e.g., pneumonia, tuberculosis)
  • Blood clots in the lungs or deep veins
  • Increased risk of certain cancers, including lymphoma
  • Liver enzyme abnormalities
  • Gastrointestinal perforations

Precautions

  • Inform your doctor about any other medications or supplements you are taking to avoid potential interactions.
  • Regularly monitor your blood counts, liver function, and lipid levels as advised by your doctor.
  • Use with caution if you have a history of chronic lung disease or a predisposition to infections.
  • Be aware of the signs of serious infections and report them to your doctor immediately.
  • Follow your doctor’s recommendations regarding vaccinations before and during treatment.

Storage Instructions

  • Store Xeljanz tablets at room temperature, between 20°C to 25°C (68°F to 77°F).
  • Keep the bottle tightly closed when not in use.
  • Protect from moisture and light.

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References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/203214s028,208246s013,213082s003lbl.pdf

Additional information

Brand Name:

Xeljanz

Scientific Name:

Tofacitinib

Other Names:

Jaknat, Xeljanz

Strength(s):

5mg, 10mg

Quantities Available:

56, 60, 112

Formulation:

Tablet

The information above is provided by third parties to Prescriptionpoint.com for Xeljanz (Tofacitinib). This information is for general purposes only and is not intended to replace a physician's advice. Always consult with your doctor or a qualified health care professional if you need advice on any medical concerns.


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