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Vytorin (ezetimibe/simvastatin)

Indications

  • Vytorin is a combination medication used to treat high cholesterol levels. It is indicated for:
  • Management of High Cholesterol (Hyperlipidemia): Vytorin is prescribed to reduce levels of total cholesterol, LDL cholesterol (bad cholesterol), and triglycerides in the blood, while also increasing HDL cholesterol (good cholesterol).
  • Prevention of Cardiovascular Events: It is used to lower the risk of heart attacks, strokes, and other cardiovascular events in people with high cholesterol or existing heart disease.

Ingredients

  • Active Ingredients: Ezetimibe and Simvastatin.
  • Inactive Ingredients: Butylated hydroxyanisole (BHA), citric acid monohydrate, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, propyl gallate, talc, titanium dioxide, and other components that help form the tablet.

Dosage and Administration

  • Take Vytorin exactly as prescribed by your healthcare provider, typically once daily in the evening.
  • Swallow the tablet whole with water; do not crush, chew, or break it.
  • Follow a cholesterol-lowering diet and exercise plan as recommended by your healthcare provider to maximize the benefits of Vytorin.
  • Regularly monitor your cholesterol levels with blood tests as advised by your doctor to ensure the medication is working effectively.
  • Avoid consuming grapefruit or grapefruit juice while taking Vytorin, as it can increase the risk of serious side effects by raising the levels of Simvastatin in your blood.
  • Do not take Vytorin if you are pregnant, planning to become pregnant, or breastfeeding, as it can harm the unborn baby or pass into breast milk.
  • Do not skip doses or stop taking Vytorin without consulting your healthcare provider, as doing so may cause your cholesterol levels to rise.
  • Avoid heavy alcohol consumption, as it can increase the risk of liver problems while on Vytorin.

Mechanism of Action

Vytorin works through two different mechanisms to lower cholesterol levels. Ezetimibe reduces the absorption of cholesterol from the small intestine, thereby decreasing the amount of cholesterol that enters the bloodstream. Simvastatin, a statin, inhibits the enzyme HMG-CoA reductase in the liver, which is involved in the production of cholesterol. Together, these actions help lower LDL cholesterol, total cholesterol, and triglycerides while increasing HDL cholesterol.

Contraindications

  • If you have a known allergy to Ezetimibe, Simvastatin, or any other ingredients in Vytorin.
  • If you have active liver disease or unexplained persistent elevations in liver enzymes, Vytorin can exacerbate liver problems.
  • If you are pregnant, planning to become pregnant, or breastfeeding, avoid using Vytorin, as it can cause harm to the fetus or infant.
  • If you are taking certain medications, such as strong CYP3A4 inhibitors (like ketoconazole or itraconazole), avoid Vytorin as it can increase the risk of serious side effects.

Side Effects

Common Side Effects:

  • Headache
  • Muscle pain or weakness
  • Upper respiratory tract infections
  • Diarrhea
  • Fatigue

Serious Side Effects:

  • Severe muscle pain, tenderness, or weakness (possible signs of rhabdomyolysis)
  • Liver problems, such as yellowing of the skin or eyes (jaundice), dark urine, or persistent nausea
  • Allergic reactions, including rash, itching, swelling, or difficulty breathing
  • Pancreatitis (symptoms may include severe abdominal pain, nausea, and vomiting)

Precautions

  • Inform your healthcare provider of any existing medical conditions, particularly liver or kidney disease, before starting Vytorin.
  • Discuss all medications, supplements, and herbal products you are taking, as Vytorin can interact with many drugs, increasing the risk of side effects.
  • Regularly monitor liver function and muscle enzyme levels through blood tests while on Vytorin to detect any early signs of adverse effects.
  • If you experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or dark urine, contact your healthcare provider immediately, as these could be signs of a serious condition.
  • Women of childbearing age should use effective contraception while taking Vytorin to avoid pregnancy.

Storage Instructions

  • Store Vytorin at room temperature, between 68°F to 77°F (20°C to 25°C), in a dry place away from moisture and heat.
  • Keep the tablets in their original packaging to protect them from light and moisture.
  • Keep Vytorin out of reach of children and pets to prevent accidental ingestion.
  • Do not store Vytorin in the bathroom or other humid environments, as moisture can degrade the tablets.

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References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021687s033s040lbl.pdf

Additional information

Brand Name:

Vytorin

Scientific Name:

Ezetimibe/Simvastatin, Ezetimibe/simvastatin

Other Names:

Inegy, Vytorin, Zimybe

Strength(s):

10/10mg, 10/20mg, 10/40mg, 10/80mg

Quantities Available:

30, 90

Formulation:

Tablet

The information above is provided by third parties to Prescriptionpoint.com for Vytorin (Ezetimibe/Simvastatin). This information is for general purposes only and is not intended to replace a physician's advice. Always consult with your doctor or a qualified health care professional if you need advice on any medical concerns.


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