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Starlix (nateglimide)

Indications

Starlix is prescribed to manage blood sugar levels in individuals with type 2 diabetes. It helps control high blood sugar, which is essential in preventing kidney damage, blindness, nerve problems, and loss of limbs.

Ingredients

• Active Ingredient: Nateglinide
• Inactive Ingredients: Calcium hydrogen phosphate, magnesium stearate, microcrystalline cellulose, povidone, starch, and hydroxypropyl cellulose.

Dosage and Administration

• Take Starlix exactly as prescribed by your healthcare provider, generally it’s 120 mg thrice daily.
• Administer the tablet 1 to 30 minutes before each main meal to help control blood sugar spikes.
• Check your blood sugar levels regularly to ensure the medication is working effectively.
• Take Starlix consistently as part of your complete diabetes management plan, including diet and exercise.
• Do not skip doses.
• Avoid heavy alcohol consumption.
• Do not double dose if you miss a dose; just proceed with your next scheduled dose.

Mechanism of Action

Nateglinide works by stimulating the pancreas to release insulin. It binds to receptors in pancreatic beta cells, leading to a rapid onset of insulin release that helps lower blood sugar levels after meals.

Contraindications

• Do not use if you are allergic to Nateglinide or any other ingredients in Starlix.
• Starlix is not suitable for treating type 1 diabetes or diabetic ketoacidosis.
• Avoid if you have severe liver disease, as it may worsen your condition.
• Do not take it with other medications that can affect blood sugar levels without consulting your doctor.

Side Effects

Common Side Effects

• Headache
• Dizziness
• Upper respiratory tract infection
• Diarrhea
• Back pain
• Joint pain

Serious Side Effects

• Hypoglycemia (low blood sugar) symptoms such as sweating, shaking, dizziness, and confusion
• Severe allergic reactions like rash, itching, swelling, severe dizziness, and trouble breathing
• Liver problems indicated by dark urine, yellowing of the skin or eyes, and severe stomach/abdominal pain

Precautions

• Inform your doctor of your complete medical history, especially if you have liver or kidney problems.
• Learn to recognize symptoms of low blood sugar and how to treat it quickly.
• Discuss all medications you are taking with your doctor to avoid potential drug interactions.
• Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Storage Instructions

• Store Starlix at room temperature, between 15°C to 30°C (59°F to 86°F).
• Store in a dry place away from light and moisture.
• Keep out of reach of children and pets.
• Do not store it in the bathroom as the humidity from showers can affect the medication.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021204s015lbl.pdf