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Salazopyrin (sulfasalazine)

Indications

• Rheumatoid Arthritis: Salazopyrin tablets are prescribed for the treatment of rheumatoid arthritis, an autoimmune disorder that causes inflammation and pain in the joints. It helps reduce symptoms such as swelling, stiffness, and pain, and slows the progression of joint damage.
• Ulcerative Colitis: This medication is also used to treat ulcerative colitis, a form of inflammatory bowel disease (IBD). It works to reduce inflammation in the colon, helping to manage symptoms like diarrhea, abdominal pain, and rectal bleeding.
• Crohn’s Disease: Salazopyrin can be used in the management of Crohn’s disease, another type of IBD, by reducing inflammation in the intestines and helping to maintain remission.

Ingredients

• Active Ingredient: Sulfasalazine.
• Inactive Ingredients: Carnauba wax, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, povidone, pregelatinized starch, and stearic acid.

Dosage and Administration

• Take Salazopyrin exactly as prescribed by your healthcare provider, usually after meals to minimize stomach upset.
• Swallow the tablet whole with a full glass of water; do not crush or chew the tablet to avoid irritation of the throat and mouth.
• Increase fluid intake to help prevent kidney stones, a potential side effect of sulfasalazine.
• Do not stop taking Salazopyrin abruptly, even if you feel better, as this may cause your symptoms to return or worsen.
• Avoid skipping doses to maintain a consistent level of the medication in your bloodstream for the best results.
• Do not take this medication if you are allergic to sulfonamides or salicylates, as it could cause a serious allergic reaction.

Mechanism of Action

Salazopyrin tablets contain sulfasalazine, which is an anti-inflammatory agent. In the body, sulfasalazine is broken down into two active components: sulfapyridine and 5-aminosalicylic acid (5-ASA). The 5-ASA component works primarily in the intestines to reduce inflammation by inhibiting the production of certain chemicals (prostaglandins and leukotrienes) that cause inflammation. This helps to alleviate the symptoms of conditions like ulcerative colitis and Crohn’s disease, as well as reducing joint inflammation in rheumatoid arthritis.

Contraindications

• Allergic Reactions: Do not use Salazopyrin if you are allergic to sulfasalazine, sulfonamides, or salicylates, as this could lead to severe allergic reactions.
• Severe Liver or Kidney Disease: Patients with significant liver or kidney impairment should not take Salazopyrin without medical supervision, as it may worsen these conditions.
• Porphyria: Salazopyrin is contraindicated in individuals with porphyria, a rare blood disorder, as it can trigger an attack.
• Intestinal or Urinary Obstruction: This medication should not be used by patients with intestinal or urinary blockages, as it may exacerbate these conditions.

Side Effects

Common Side Effects:

• Nausea
• Vomiting
• Loss of appetite
• Headache
• Rash

Serious Side Effects:

• Severe abdominal pain
• Yellowing of the skin or eyes (jaundice)
• Unusual bruising or bleeding
• Difficulty breathing
• Severe allergic reactions (e.g., hives, swelling of the face, lips, tongue, or throat)

Precautions

• Regular blood tests may be required to monitor your liver function and blood cell counts while taking Salazopyrin, as it can affect these.
• Inform your healthcare provider if you have a history of liver or kidney disease, asthma, or severe allergies before starting this medication.
• Limit sun exposure and use sunscreen, as sulfasalazine can make your skin more sensitive to sunlight, increasing the risk of sunburn.
• Take folic acid supplements as advised by your healthcare provider, since Salazopyrin can interfere with folic acid absorption, potentially leading to deficiency.

Storage Instructions

• Store Salazopyrin tablets at room temperature, between 20°C and 25°C (68°F and 77°F), in a tightly closed container.
• Keep the medication away from moisture and direct light to maintain its effectiveness.
• Store Salazopyrin out of reach of children and pets to prevent accidental ingestion.

Why Choose Our Online Pharmacy for Salazopyrin?

Authenticity and Safety

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Prescription Requirement: We prioritize your well-being by requiring a valid prescription from a healthcare provider, ensuring that Salazopyrin is suitable for your condition.

Cost and Savings

Affordable Pricing: PrescriptionPoint provides some of the most competitive prices for Salazopyrin online, helping you reduce your drug expenses.

Generic Alternatives: Besides the brand-name Salazopyrin, we offer generic Sulfasalazine, which is just as effective and more budget friendly.

Customer Service

Our committed customer service team is always available to help with any questions or issues, ensuring a seamless purchasing experience.

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How to Order Salazopyrin Online in Canada?

Online

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Phone

For personalized assistance, you can place your order for Salazopyrin by speaking with one of our friendly customer support representatives. Just call us on +1-877-244-0431, and we will be happy to assist you.

Fax

If you prefer using fax, you can send your prescription and details to our secure fax line at +1-877-453-0921. We ensure quick and confidential processing of your order.

References

https://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/040349.pdf