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Salagen (pilocarpine)

Indications

Salagen is used to treat dry mouth caused by Sjögren’s syndrome or by radiation therapy for head and neck cancer.

Dosage and Administration

• Take Salagen exactly as prescribed by your doctor.
• Swallow the tablets whole with a full glass of water.
• Take the medication with or without food, but consistently follow your doctor’s recommendations.
• Follow your doctor’s instructions on the dosage and schedule, typically taken several times daily.
• Do not crush, chew, or break the tablets.
• Avoid skipping doses.
• Do not take more than the prescribed dose to prevent potential side effects or overdose.
• Avoid consuming alcohol while taking Salagen, as it may increase the risk of side effects.
• Do not stop taking Salagen without consulting your doctor, even if you feel better.

Mechanism of Action

Salagen (Pilocarpine) works by stimulating the muscarinic receptors in the salivary glands, which increases the secretion of saliva. This helps to alleviate dry mouth symptoms by promoting natural saliva production.

Contraindications

• Do not use it if you are allergic to Pilocarpine or any ingredients in Salagen.
• Avoid use if you have uncontrolled asthma, severe heart disease, or conditions where increased sweating is not advisable.
• Not recommended for individuals with narrow-angle glaucoma.
• Consult your doctor if you have a history of liver disease, kidney disease, or gallbladder disease before taking this medication.

Side Effects

Common Side Effects:

• Sweating
• Nausea
• Runny nose
• Diarrhea
• Chills
• Flushing
• Increased urination

Serious Side Effects:

• Severe allergic reactions (rash, itching, swelling of the face/tongue/throat)
• Vision changes or eye pain
• Severe abdominal pain
• Persistent diarrhea or vomiting
• Heart rhythm changes (palpitations or irregular heartbeat)
• Difficulty breathing or shortness of breath

Precautions

• Inform your doctor of any existing health conditions.
• Regularly monitor for any side effects and report any severe or unusual symptoms to your healthcare provider.
• Avoid activities that require alertness until you know how Salagen affects you, as it may cause dizziness or drowsiness.

Storage Instructions

• Store Salagen tablets at room temperature between 68°F and 77°F (20°C and 25°C).
• Keep the medication in its original container, tightly closed, and away from moisture and light.
• Do not store it in the bathroom to avoid exposure to humidity.
• Keep out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/020237s012lbl.pdf