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Renagel (sevelamer hydrochloride) 

Indications 

Renagel is used to control high blood levels of phosphorus in patients with chronic kidney disease who are on dialysis. It helps prevent complications associated with high phosphorus levels, such as bone disease and cardiovascular issues. 

Dosage and Administration 

• Take Renagel exactly as prescribed by your doctor. 
• Swallow the tablets whole with meals to ensure it works properly in binding dietary phosphate. 
• Follow your doctor’s instructions on the dosage, typically based on your serum phosphorus level. 
• Drink plenty of fluids unless otherwise directed by your healthcare provider. 
• Do not crush, chew, or break the tablets. 
• Avoid taking more than the prescribed dose to prevent potential side effects. 
• Do not stop taking Renagel without consulting your doctor, even if you feel well. 
• Avoid taking the medication on an empty stomach as it is designed to bind to phosphorus in the food. 
• Do not skip doses; take the tablets consistently as prescribed. 

Mechanism of Action 

Renagel (Sevelamer Hydrochloride) is a phosphate binder that works by binding to phosphate in the digestive tract. This prevents phosphate from being absorbed into the bloodstream, thereby reducing serum phosphate levels. By controlling phosphate levels, Renagel helps to prevent the complications of hyperphosphatemia in patients with chronic kidney disease on dialysis. 

Contraindications 

• Do not use it if you are allergic to Sevelamer Hydrochloride or any ingredients in Renagel. 
• Avoid if you have bowel obstruction or severe constipation. 
• Not recommended for individuals with dysphagia (difficulty swallowing) or severe gastrointestinal motility disorders. 
• Consult your doctor if you have a history of gastrointestinal surgery or disorders before taking this medication. 
• Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. 

Side Effects 

Common Side Effects: 

• Nausea 
• Vomiting 
• Diarrhea 
• Indigestion 
• Stomach pain 
• Flatulence (gas) 
• Constipation 

Serious Side Effects: 

• Severe abdominal pain 
• Difficulty swallowing 
• Signs of gastrointestinal obstruction (severe constipation, vomiting, bloating) 
• Allergic reactions (rash, itching, swelling of the face/tongue/throat) 

Precautions 

• Inform your doctor of any existing health conditions, especially gastrointestinal disorders or difficulty swallowing. 
• Regularly monitor your blood phosphorus levels as advised by your healthcare provider. 
• Take Renagel with meals to ensure proper binding of dietary phosphate. 
• Avoid consuming high-phosphorus foods and follow dietary recommendations provided by your healthcare provider. 
• Discuss all medications, supplements, and herbal products you are taking with your healthcare provider to avoid interactions. 

Storage Instructions 

• Store Renagel tablets at room temperature between 68°F and 77°F (20°C and 25°C). 
• Keep the medication in its original container, tightly closed, and away from moisture and light. 
• Do not store it in the bathroom to avoid exposure to humidity. 
• Keep out of reach of children and pets. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021179s032lbl.pdf