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Pulmicort Respules (budesonide inhalation suspension)

Indications

• Asthma Maintenance Therapy Used to prevent asthma attacks (bronchospasms) in adults and children who require ongoing treatment.
• Chronic Obstructive Pulmonary Disease (COPD) Helps reduce inflammation in the airways and improve breathing in patients with COPD.
• Nebulization Therapy Can be used with a nebulizer for severe asthma attacks or exacerbations under medical supervision.

Dosage and Administration

• Follow your doctor’s prescribed dosage and nebulization instructions strictly.
• Use the prescribed nebulizer device with the correct amount of medication as directed.
• Breathe normally through the mouthpiece until all the medication is inhaled.
• Rinse your mouth with water and spit it out after each use to prevent throat irritation.
• Clean and disinfect the nebulizer according to the manufacturer’s instructions after each use.
• Do not mix with other medications in the nebulizer unless instructed by your doctor.
• Avoid using the medication if the respules packaging is damaged or if the medication has expired.
• Do not share your nebulizer equipment or medication with others, even if they have similar symptoms.
• Do not use for sudden asthma attacks; use a rescue inhaler (e.g., albuterol) for acute symptoms.

Mechanism of Action

Budesonide inhalation suspension is a corticosteroid that works by reducing inflammation in the airways. It inhibits the release of inflammatory substances in the lungs, thereby preventing asthma attacks and improving symptoms of COPD.

Contraindications

• Do not use it if you are allergic to budesonide or any component of the inhalation suspension.
• Avoid during acute asthma exacerbations; use short-acting bronchodilators instead.
• Not suitable for patients with untreated fungal, bacterial, or viral infections of the respiratory tract.
• Avoid in patients with tuberculosis or recent exposure to tuberculosis.

Side Effects

Common Side Effects

• Sore throat
• Hoarseness
• Cough
• Headache
• Nasal congestion

Serious Side Effects

• Severe allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)
• Signs of a fungal infection (white patches in your mouth or throat)
• Vision changes (blurred vision, halos around lights)
• Rapid heartbeat
• Unusual tiredness

Precautions

• Inform your doctor about any other medications you are taking to avoid interactions.
• Disclose your complete medical history, especially of infections, osteoporosis, and adrenal gland problems.
• Use with caution in patients with liver disease or diabetes.
• Monitor bone density if using long-term, as corticosteroids may increase the risk of osteoporosis.
• Avoid exposure to chickenpox or measles if not immune, as corticosteroids can worsen these infections.

Storage Instructions

• Store unopened respules in the refrigerator between 36°F to 46°F (2°C to 8°C).
• Protect from light.
• Once opened, store at room temperature below 77°F (25°C) and use within 2 weeks.
• Keep out of reach of children and pets.
• Dispose of used respules and nebulizer accessories properly, following local disposal regulations.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/020929s052lbl.pdf