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Protonix (pantoprazole)

Indications

Protonix is used for the treatment and management of:

• Short-term treatment (7 to 10 days) of Gastroesophageal Reflux Disease (GERD) associated with a history of erosive esophagitis.
• Pathological hypersecretory conditions including Zollinger-Ellison Syndrome. 

Dosage and Administration

• Read the Medication Guide provided by your pharmacist before starting Protonix and each time you get a refill. If you have any questions, ask your healthcare provider.
• Take Protonix by mouth as directed by your healthcare provider, usually once daily.
• Take tablets with or without food.
• Swallow the tablets whole.
• Use this medication regularly to get the most benefit. Take it at the same time each day.
• Continue taking Protonix for the prescribed length of treatment even if you feel better.
• Inform your healthcare provider if your condition persists or worsens.
• Do not split, crush, or chew Protonix tablets.

Mechanism of Action

Pantoprazole, the active ingredient in Protonix, is a proton pump inhibitor (PPI). It works by blocking the enzyme in the stomach wall that produces acid, reducing the amount of acid in the stomach. This helps treat acid-related conditions of the stomach and esophagus.

Contraindications

Protonix should not be used in patients with known hypersensitivity to any component of the formulation or to substituted Benzimidazoles.

Side Effects

Common Side Effects

• Headache 
• Diarrhea 
• Nausea 
• Stomach pain 
• Vomiting 
• Gas 
• Dizziness 
• Joint pain 
• Flatulence 
• Cold-like symptoms (sore throat, congested nose, sneezing).

Serious Side Effects

• Symptoms of low magnesium levels (such as muscle spasms, irregular heartbeat, seizures)
• Signs of lupus (such as rash on nose and cheeks, new or worsening joint pain)
• Seizures
• Trouble breathing
• Watery or bloody diarrhea
• Blurred vision
• Dry mouth
• Flushed dry skin
• Fruit-like breath odor
• Increased hunger
• Increased thirst
• Increased urination
• Sweating
• Unexplained weight loss
• Elevated liver enzymes

Precautions

• In adults, a response to Protonix does not rule out gastric cancer. If you have a suboptimal response or early relapse, you may need additional follow-up and diagnostic testing. If you are older, consider getting an endoscopy.
• Protonix can cause acute tubulointerstitial nephritis (TIN) at any point. If you suspect you have acute TIN, stop taking Protonix and seek evaluation.
• Be aware that Protonix may be associated with serious adverse reactions, including Clostridium difficile-associated diarrhea, bone fractures, severe skin reactions, cutaneous and systemic lupus erythematosus, vitamin B-12 deficiency, low magnesium levels, and fundic gland polyps. If you experience any of these issues, contact your healthcare provider.

Storage Instructions

Store at room temperature between 59°F to 86°F (15°C to 30°C).

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020988s044lbl.pdf  

https://www.drugs.com/pro/protonix.html