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Pravachol (pravastatin sodium)

Indications

• Pravachol is used to lower high levels of cholesterol in your blood, helping to reduce the risk of heart disease.
• It is prescribed to reduce your risk of heart attack, stroke, and other heart-related complications, whether or not you already have coronary heart disease.
• Pravachol helps manage mixed dyslipidemia by lowering your bad cholesterol (LDL) and triglycerides while increasing your good cholesterol (HDL).
• It is used to reduce your risk of additional heart attacks and the need for heart surgery if you have already had a heart attack.

Dosage and Administration

• Take Pravachol exactly as your doctor prescribes. Usually, you will take it once daily.
• Take Pravachol at the same time each day to maintain an even level of the medication in your body.
• You can take Pravachol with or without food.
• Have your cholesterol levels checked regularly to monitor how well Pravachol is working for you.
• Do not skip doses. Missing doses can decrease the effectiveness of the medication.
• Avoid drinking alcohol while taking Pravachol, as it can increase your risk of liver problems.
• Do not take more than the prescribed dose, as it can increase your risk of severe side effects.
• Do not take Pravachol if you are pregnant or planning to become pregnant, as it can harm your unborn baby.

Mechanism of Action

Pravachol works by inhibiting an enzyme called HMG-CoA reductase, which is essential for the production of cholesterol in your liver. By blocking this enzyme, Pravachol reduces your levels of bad cholesterol (LDL) and triglycerides in your blood while slightly increasing your levels of good cholesterol (HDL). This helps prevent the buildup of cholesterol in your arteries, reducing your risk of heart disease and stroke.

Contraindications

• Do not take Pravachol if you have active liver disease or unexplained persistent elevations of liver enzymes.
• Do not use Pravachol if you are pregnant or planning to become pregnant, as it can harm your unborn baby.
• Do not take Pravachol while breastfeeding, as it can pass into your breast milk and harm your baby.
• Avoid Pravachol if you have a known allergy to pravastatin or any of its ingredients.

Side Effects

Common Side Effects

• Headache
• Nausea
• Muscle pain
• Fatigue
• Dizziness

Serious Side Effects

• Severe muscle pain or weakness, which may indicate muscle breakdown
• Liver problems, such as jaundice, dark urine, and severe stomach pain
• Allergic reactions, including rash, itching, swelling, severe dizziness, and trouble breathing

Precautions

• Inform your doctor about any other medications you are taking, including over-the-counter drugs and supplements.
• Contact your doctor if you experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or feeling unwell.
• Regular blood tests are needed to monitor your liver function while taking Pravachol.
• Limit your alcohol intake, as alcohol can increase the risk of liver problems.
• If you have diabetes, monitor your blood glucose levels closely, as Pravachol may increase blood sugar levels.

Storage Instructions

• Store Pravachol at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the tablets in a dry place and in their original container, tightly closed.
• Store Pravachol out of reach of children and pets.
• Do not store Pravachol in extreme heat or cold.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019898s062lbl.pdf