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Prandin (repaglinide)

Indications

Prandin is used to control blood sugar levels in adults with type 2 diabetes. It is taken in conjunction with diet and exercise to improve blood glucose control.

Dosage and Administration

• Take Prandin exactly as prescribed by your doctor.
• Administer the tablet orally before meals, typically 2 to 4 times daily.
• Follow your doctor’s instructions regarding the timing of doses, usually 15-30 minutes before eating.
• Monitor your blood sugar levels regularly as advised by your healthcare provider.
• Do not take Prandin if you are planning to skip a meal to avoid the risk of hypoglycemia (low blood sugar).
• Avoid taking more than the prescribed dose to prevent potential side effects.
• Do not crush or chew the tablets, as it may affect the drug’s effectiveness.
• Do not stop taking Prandin without consulting your doctor, even if you feel well.

Mechanism of Action

Prandin (Repaglinide) is a meglitinide analog that stimulates the pancreas to release insulin. It works by closing ATP-dependent potassium channels in the pancreatic beta-cell membrane, leading to the opening of calcium channels. This action results in increased intracellular calcium, which stimulates insulin release from the pancreatic beta cells. This helps to lower blood glucose levels in individuals with type 2 diabetes.

Contraindications

• Do not use it if you are allergic to repaglinide or any ingredients in Prandin.
• Avoid if you have diabetic ketoacidosis (a serious diabetes complication).
• Not recommended for use in type 1 diabetes.
• Consult your doctor if you have liver problems before taking this medication.

Side Effects

Common Side Effects:

• Hypoglycemia (low blood sugar)
• Headache
• Nausea
• Diarrhea
• Joint pain
• Upper respiratory infection

Serious Side Effects:

• Severe hypoglycemia (confusion, seizures, loss of consciousness)
• Chest pain
• Allergic reactions (rash, itching, swelling of the face/tongue/throat)
• Jaundice (yellowing of skin or eyes)
• Liver dysfunction

Precautions

• Regularly monitor blood sugar levels and be aware of the symptoms of hypoglycemia.
• Carry a source of sugar, such as glucose tablets or candy, in case of low blood sugar episodes.
• Adjustments to diet, exercise, and medication may be necessary during periods of stress, illness, or surgery.
• Discuss all medications, supplements, and herbal products you are taking with your healthcare provider to avoid interactions.

Storage Instructions

• Store Prandin tablets at room temperature between 68°F and 77°F (20°C and 25°C).
• Keep the medication in its original container, tightly closed, and away from moisture and light.
• Do not store it in the bathroom to avoid exposure to humidity.
• Keep out of reach of children and pets.
• Dispose of any expired or unused medication properly, following the guidance of your pharmacist.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020741s035lbl.pdf