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Polytrim (polymyxin b/trimethoprim)

Indications

• Polytrim is used to treat bacterial infections of the eye, commonly known as pink eye.
• Effective in treating infections involving both the eyelid and the conjunctiva.
• Used to prevent infections in the eye following surgery or injury.

Dosage and Administration

• Use Polytrim exactly as prescribed by your doctor.
• Wash your hands thoroughly before applying the eye drops.
• Tilt your head back and pull down the lower eyelid to create a small pocket before applying the drops.
• Apply the prescribed number of drops into the eye and close your eyes for 1-2 minutes.
• Follow your doctor’s instructions regarding the frequency and duration of use.
• Do not touch the dropper tip on any surface, including your eye, to avoid contamination.
• Avoid wearing contact lenses while using Polytrim unless advised by your doctor.
• Do not skip doses; apply the drops at regular intervals as prescribed.
• Do not share eye drops with anyone else.
• Do not stop using Polytrim without consulting your doctor, even if symptoms improve.

Mechanism of Action

Polytrim contains two antibiotics: Polymyxin B and Trimethoprim. Polymyxin B disrupts the bacterial cell membrane, causing cell death, while Trimethoprim inhibits bacterial DNA synthesis by blocking the production of folic acid. Together, they effectively eliminate the bacteria causing the infection.

Contraindications

• Do not use it if you are allergic to Polymyxin B, Trimethoprim, or any other components of Polytrim.
• Avoid use if you have a viral or fungal eye infection.
• Not recommended for use in children under two months of age without medical advice.
• Consult your doctor if you have a history of allergies or any other eye conditions before using this medication.
• Inform your healthcare provider if you are pregnant or breastfeeding.

Side Effects

Common Side Effects:

• Mild burning or stinging in the eye
• Itching or redness of the eye
• Watery eyes
• Temporary blurred vision

Serious Side Effects:

• Severe eye pain
• Vision changes
• Persistent redness or swelling
• Allergic reactions (rash, itching, swelling of the face/tongue/throat)

Precautions

• Inform your doctor of any existing health conditions, especially allergies or other eye conditions.
• Avoid touching the dropper tip to any surface to prevent contamination.
• Do not drive or operate heavy machinery until you know how the eye drops affect your vision.
• Discuss all medications, supplements, and herbal products you are taking with your healthcare provider to avoid interactions.

Storage Instructions

• Store Polytrim eye drops at room temperature between 59°F and 77°F (15°C and 25°C).
• Keep the bottle tightly closed when not in use.
• Protect the eye drops from light and moisture.
• Do not store it in the bathroom to avoid exposure to humidity.
• Keep out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/060716Orig1s020Lbl.pdf