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Pletal (cilostazol) 

Indications 

Used to improve symptoms of intermittent claudication, such as pain and cramping in the legs during exercise, by increasing blood flow to the limbs. 

Dosage and Administration 

• Take the tablet exactly as prescribed by your doctor. 
• Swallow the tablet whole with a full glass of water. 
• Take the medication 30 minutes before or 2 hours after breakfast and dinner for better absorption. 
• If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. In that case, skip the missed dose. 
• Follow your doctor’s instructions regarding any dietary restrictions. 
• Inform your doctor about all medications and supplements you are taking to avoid interactions.
• Do not exceed the prescribed dose. 
• Do not crush or chew the tablet. 
• Do not take the medication with grapefruit juice, as it can increase side effects. 
• Do not abruptly stop taking the medication without consulting your doctor. 
• Do not take Pletal if you have a history of heart failure. 

Mechanism of Action 

Pletal (Cilostazol) works by inhibiting the enzyme phosphodiesterase III (PDE III), which increases levels of cyclic AMP in platelets and blood vessels. This leads to inhibition of platelet aggregation and dilation of blood vessels, improving blood flow and reducing symptoms of intermittent claudication. 

Contraindications 

• Heart Failure: Do not use the medication if you have any type of heart failure. 
• Allergic Reaction: Avoid if you are allergic to Cilostazol or any of its ingredients. 
• Bleeding Disorders: Not recommended if you have a bleeding disorder or active bleeding. 
• Severe Kidney or Liver Disease: Consult your doctor before use if you have severe kidney or liver disease. 

Side Effects 

Common Side Effects:

• Headache 
• Diarrhea 
• Dizziness 
• Palpitations 
• Abnormal stools 
• Runny nose

Serious Side Effects:

• Fast or irregular heartbeat 
• Severe dizziness or fainting 
• Signs of infection (fever, sore throat) 
• Unusual bleeding or bruising 
• Chest pain 
• Severe allergic reactions (rash, itching, swelling) 

Precautions 

• Inform about Medical History: Let your doctor know if you have a history of heart disease, high blood pressure, kidney or liver issues, or any other medical conditions. 
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding. 
• Avoid Grapefruit: Do not consume grapefruit or grapefruit juice while taking this medication, as it can increase the risk of side effects. 
• Regular Monitoring: Attend regular check-ups to monitor your progress and any potential side effects. 
• Avoid Heavy Machinery: Be cautious when driving or operating heavy machinery until you know how the medication affects you, as it can cause dizziness. 

Storage Instructions 

• Keep the tablets at a temperature between 59°F and 86°F (15°C to 30°C). 
• Store in a dry place, away from excessive moisture and light. 
• Ensure the medication is stored securely away from children and pets. 
• Dispose of unused or expired tablets properly, following local regulations or pharmacy guidelines. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020863s024lbl.pdf