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Plendil (felodipine)

Indications

• Plendil is used to treat high blood pressure, helping to prevent strokes, heart attacks, and kidney problems.
• Helps to relieve chest pain due to reduced blood flow to the heart.
• Sometimes used to treat this condition, which causes reduced blood flow to the fingers and toes.

Dosage and Administration

• Take Plendil exactly as prescribed by your doctor.
• Swallow the tablets whole with a full glass of water.
• Take the medication consistently at the same time each day.
• Follow your doctor’s advice regarding diet, exercise, and other medications to manage blood pressure effectively.
• Inform your doctor about all medications and supplements you are currently taking.
• Do not crush or chew the tablets, as this can release all the drug at once and increase the risk of side effects.
• Avoid consuming grapefruit or grapefruit juice while taking Plendil, as it can interfere with the medication.
• Do not skip doses; if you miss a dose, take it as soon as you remember unless it is almost time for the next dose.
• Avoid taking double doses to make up for a missed dose.
• Do not stop taking Plendil without consulting your doctor, even if you feel well.

Mechanism of Action

Plendil (felodipine) is a calcium channel blocker that works by relaxing the muscles of your heart and blood vessels. It inhibits the influx of calcium ions during depolarization of cardiac and vascular smooth muscle, leading to vasodilation and reduced blood pressure. This action helps to ease the workload on the heart and improve blood flow.

Contraindications

• Do not use it if you are allergic to Felodipine or any of the ingredients in Plendil.
• Avoid if you have severe aortic stenosis (narrowing of the aorta).
• Not recommended if you have unstable angina or recent heart attack without consulting your doctor.
• Consult your doctor if you have liver problems before taking this medication.
• Inform your healthcare provider if you are pregnant or breastfeeding.

Side Effects

Common Side Effects:

• Headache
• Dizziness
• Swelling of the ankles or feet
• Flushing
• Fatigue

Serious Side Effects:

• Severe dizziness or fainting
• Irregular heartbeat
• Chest pain
• Shortness of breath
• Signs of liver problems (yellowing of skin or eyes, dark urine)

Precautions

• Inform your doctor of any existing health conditions, including heart, liver, or kidney diseases.
• Regularly monitor your blood pressure and heart rate while taking Plendil.
• Use the medication with caution if you have low blood pressure.
• Avoid operating heavy machinery or driving if you experience dizziness or drowsiness.
• Discuss all medications, supplements, and herbal products you are taking with your healthcare provider to avoid interactions.

Storage Instructions

• Store Plendil at room temperature between 68°F and 77°F (20°C and 25°C).
• Keep the medication in its original container, tightly closed, and away from moisture and light.
• Do not store it in the bathroom to avoid exposure to humidity.
• Keep out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019834s025lbl.pdf