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Periostat (doxycycline hyclate)

Indications

• Periostat capsules are prescribed as an adjunct treatment for adult periodontitis (gum disease) to reduce inflammation and progression of the condition.
• They are also used to manage acne vulgaris when conventional treatments have not been effective.

Dosage and Administration

• Take Periostat capsules exactly as prescribed by your healthcare provider.
• Swallow the capsule whole with a full glass of water.
• Take Periostat on an empty stomach, at least 1 hour before or 2 hours after meals, unless otherwise directed by your doctor.
• Do not crush, chew, or break the capsule.
• Avoid taking Periostat with dairy products, antacids, or iron supplements, as they can decrease the absorption of the medication.
• Do not take Periostat close to bedtime, as it may cause irritation of the esophagus (food pipe).

Mechanism of Action

Periostat contains Doxycycline, a tetracycline antibiotic. It works by inhibiting the growth of bacteria associated with gum disease and acne. Additionally, it has anti-inflammatory properties that help reduce gum inflammation.

Contraindications

• Do not use Periostat capsules if you are allergic to Doxycycline or any other tetracycline antibiotics.
• Avoid Periostat if you are pregnant or breastfeeding, as it can affect fetal bone growth and tooth development.
• Periostat is not recommended for children under 8 years old due to the risk of tooth discoloration and inhibition of bone growth.

Side Effects

Common Side Effects:

• Nausea
• Vomiting
• Diarrhea
• Skin sensitivity to sunlight (photosensitivity)
• Tooth discoloration (in children under 8 years old)

Serious Side Effects:

• Severe allergic reactions (rash, itching, swelling)
• Severe diarrhea (with blood or mucus)
• Intracranial hypertension (severe headache, blurred vision, nausea)

Precautions

• Inform your doctor about any existing medical conditions, especially kidney or liver problems, before starting treatment with Periostat.
• Use sunscreen and protective clothing while outdoors, as Periostat may increase sensitivity to sunlight.
• Do not use outdated or expired Periostat capsules.

Storage Instructions

• Store Periostat at room temperature between 68°F to 77°F (20°C to 25°C).
• Keep the capsules in their original container, tightly closed and protected from moisture and heat.
• Keep out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/50783slr002_periostat_lbl.pdf