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Pentasa (mesalazine)

Indications

• Pentasa prolonged-release tablets are prescribed for the treatment of mild to moderate ulcerative colitis, a type of inflammatory bowel disease (IBD).
• They help reduce inflammation in the colon and rectum, relieving symptoms such as diarrhea, rectal bleeding, and abdominal pain.

Dosage and Administration

• Take Pentasa tablets exactly as prescribed by your healthcare provider.
• Swallow the tablets whole with a glass of water.
• Take Pentasa with food or a meal to reduce the risk of stomach upset.
• Do not crush, chew, or break the tablets.
• Do not take antacids that contain calcium while using Pentasa, as they may interfere with the release of the medication.
• Do not stop taking Pentasa abruptly without consulting your doctor, even if you feel better.

Mechanism of Action

Pentasa tablets contain Mesalazine, which belongs to a class of medications known as aminosalicylates. It works by reducing inflammation in the colon and rectum by inhibiting the production of inflammatory chemicals and decreasing immune response.

Contraindications

• Do not use Pentasa if you are allergic to Mesalazine or any other ingredients in the tablets.
• Avoid Pentasa if you have severe kidney disease or liver disease.
• Pentasa is not recommended during pregnancy or breastfeeding without medical advice.

Side Effects

Common Side Effects:

• Headache
• Nausea
• Abdominal pain
• Diarrhea
• Flatulence (gas)

Serious Side Effects:

• Severe allergic reactions (rash, itching, swelling)
• Pancreatitis (severe abdominal pain, nausea, vomiting)
• Liver problems (yellowing of the skin or eyes, dark urine)
• Worsening of colitis symptoms

Precautions

• Inform your doctor about any existing medical conditions, especially kidney or liver problems, before starting treatment with Pentasa.
• Monitor kidney function periodically while on Pentasa therapy.
• If you notice persistent or severe abdominal pain, bloody diarrhea, or signs of an allergic reaction, seek medical attention immediately.

Storage Instructions

• Store Pentasa at room temperature between 68°F to 77°F (20°C to 25°C).
• Keep the tablets in their original container, tightly closed and protected from moisture and heat.
• Keep out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/020049s032lbl.pdf