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Optimmune (cyclosporine)

Indications

• Optimmune eye ointment is indicated for the treatment of keratoconjunctivitis sicca (dry eye syndrome) in dogs.
• Used to manage chronic dry eye conditions by increasing tear production and reducing inflammation.

Dosage and Administration

• Apply Optimmune exactly as prescribed by your veterinarian, usually twice daily.
• Wash your hands thoroughly before applying the ointment.
• Tilt your pet’s head back, gently pull down the lower eyelid to create a small pocket, and apply a small amount (about ¼ inch) of the ointment into the pocket.
• Allow your pet to blink to spread the ointment over the surface of the eye.
• Use a separate tube for each eye if instructed by your veterinarian to avoid cross-contamination.
• Store in a dry place, away from moisture and heat.
• Do not touch the tube tip to any surface, including the eye, to avoid contamination.
• Avoid using other eye medications unless prescribed by your veterinarian and spaced at least 5 minutes apart from Optimmune.
• Do not skip doses or stop using the ointment without consulting your veterinarian, even if your pet’s symptoms improve.
• Do not allow your pet to rub their eyes immediately after application to prevent irritation or removal of the ointment.

Mechanism of Action

Optimmune contains cyclosporine, an immunosuppressive agent that works by inhibiting the activation of T-cells. This reduces inflammation in the tear glands and stimulates increased tear production, helping to alleviate the symptoms of dry eye syndrome.

Contraindications

• Do not use Optimmune if your pet has a known allergy to cyclosporine or any other ingredients in the ointment.
• Avoid using Optimmune if your pet has an active eye infection or other serious eye condition without consulting your veterinarian.

Side Effects

Common Side Effects

• Mild burning or stinging sensation in the eye
• Temporary blurred vision
• Increased tear production
• Redness or irritation of the eye

Serious Side Effects

• Severe allergic reactions (rash, itching, swelling, difficulty breathing)
• Eye pain or significant changes in vision
• Persistent or worsening eye redness or irritation

Precautions

• Inform your veterinarian about any existing medical conditions, especially eye problems, before using Optimmune.
• Be cautious if your pet is pregnant, planning to become pregnant, or breastfeeding; discuss the risks and benefits with your veterinarian.
• Regularly monitor the condition of your pet’s eyes while using the ointment, and consult your veterinarian if symptoms worsen or do not improve.
• Avoid letting your pet swim or bathe immediately after application to prevent the ointment from washing out.
• Inform your veterinarian about all medications, including over-the-counter drugs and supplements, to avoid potential interactions.

Storage Instructions

• Store Optimmune eye ointment at room temperature (15°C to 25°C) in a dry place, away from moisture and heat.
• Keep the tube tightly closed when not in use.
• Do not use Optimmune if the ointment shows signs of contamination or changes in consistency.
• Dispose of any unused or expired ointment properly, following local regulations or guidelines.
• Keep Optimmune out of reach of children and pets.

References

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8ee9c677-d86c-4f2f-9eec-6998f4394ae1