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Norvasc (amlodipine)

Indications

• Hypertension (High Blood Pressure): Norvasc is used to treat high blood pressure, helping to prevent strokes, heart attacks, and kidney problems.
• Angina (Chest Pain): It is prescribed to relieve chest pain and reduce the number of angina attacks.
• Coronary Artery Disease: Norvasc is used in patients with certain types of heart disease to improve exercise tolerance and decrease the risk of cardiovascular events.

Dosage and Administration

• Take Norvasc exactly as prescribed by your doctor.
• Swallow the tablet whole with a full glass of water.
• Take the tablet at the same time each day to maintain consistent levels of the medication in your body.
• If you miss a dose, take it as soon as you remember unless it is almost time for your next dose.
• Monitor your blood pressure regularly to ensure the medication is working effectively.
• Do not take more than the recommended dose.
• Avoid skipping doses or stopping the medication without consulting your doctor.
• Do not consume grapefruit or grapefruit juice while taking Norvasc, as it can increase the risk of side effects.
• Avoid drinking alcohol as it can further lower your blood pressure and increase side effects.

Mechanism of Action

Norvasc is a calcium channel blocker that works by relaxing the blood vessels so that blood can flow more easily. It reduces the workload on the heart and helps to lower blood pressure, relieve chest pain, and prevent heart attacks.

Contraindication

• Do not use Norvasc if you are allergic to amlodipine or any other components of the tablet.
• Avoid use if you have severe low blood pressure (hypotension).
• Not recommended for use in patients with cardiogenic shock (a condition where the heart cannot pump enough blood to the body).
• Avoid if you have aortic stenosis (narrowing of the aortic valve in the heart).

Side Effects

Common Side Effects

• Swelling of the legs or ankles
• Dizziness or lightheadedness
• Flushing (warmth, redness, or tingly feeling)
• Fatigue
• Nausea
• Palpitations (irregular heartbeat)

Serious Side Effects

• Severe allergic reactions (e.g., rash, itching, swelling, severe dizziness, trouble breathing)
• Severe hypotension (very low blood pressure)
• Heart attack symptoms (e.g., chest pain, shortness of breath, pain spreading to your jaw or shoulder)
• Liver problems (e.g., yellowing of the skin or eyes, dark urine)
• Increased chest pain or worsening of angina

Precautions

• Inform your doctor of any pre-existing conditions, especially heart disease, liver disease, or severe low blood pressure.
• Be cautious when driving or operating heavy machinery until you know how Norvasc affects you.
• Inform your doctor about all medications, supplements, and herbal products you are taking to avoid harmful interactions.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits with your doctor.
• Stay hydrated and avoid overheating during exercise to prevent dizziness or fainting.

Storage Instructions

• Store Norvasc tablets at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the medication in its original container, tightly closed, and out of reach of children.
• Protect from light and moisture.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019787s047lbl.pdf