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Nevanac (nepafenac)

Indications

• Nevanac ophthalmic suspension is indicated for the treatment of pain and inflammation associated with cataract surgery.
• Used to reduce the risk of macular edema following cataract surgery in diabetic patients.

Dosage and Administration

• Use Nevanac exactly as prescribed by your doctor, usually one drop in the affected eye(s) three times daily beginning 1 day before cataract surgery.
• Continue using it on the day of surgery and for the first 2 weeks following surgery.
• Shake the bottle well before each use.
• Wash your hands before and after applying the drops.
• Tilt your head back and pull down your lower eyelid to create a small pocket.
• Place one drop into the pocket and close your eyes gently.
• Wait at least 5 minutes before using any other eye medications your doctor has prescribed.
• Do not touch the dropper tip or let it touch your eye or any other surface to avoid contamination.
• Avoid using more drops than prescribed, as it will not speed up the healing process.
• Do not stop using Nevanac suddenly without consulting your doctor, even if your symptoms improve.
• Do not wear contact lenses while using Nevanac unless your doctor tells you to.

Mechanism of Action

Nevanac contains Nepafenac, a nonsteroidal anti-inflammatory drug (NSAID). It works by inhibiting the enzyme cyclooxygenase (COX), which results in a decrease in the formation of prostaglandins, compounds that cause pain and inflammation. By reducing prostaglandin production, Nevanac helps to alleviate pain and inflammation associated with eye surgery.

Contraindications

• Do not use Nevanac if you have a known allergy to Nepafenac, any other NSAIDs, or any other ingredients in the suspension.
• Avoid using Nevanac if you have a history of asthma attacks, hives, or allergic reactions after taking aspirin or other NSAIDs.

Side Effects

Common Side Effects:

• Eye pain or discomfort
• Increased tear production
• Blurred vision
• Sensation of a foreign body in the eye
• Itching or redness of the eye

Serious Side Effects:

• Severe eye irritation or redness
• Eye swelling
• Changes in vision
• Signs of an eye infection (e.g., discharge, crusting of the eyelids)
• Severe allergic reactions (rash, itching, swelling, difficulty breathing)

Precautions

• Inform your doctor about any existing medical conditions or medications you are taking before using Nevanac.
• Be cautious if you have a history of bleeding disorders, as NSAIDs can increase the risk of bleeding.
• Regularly monitor your eye health during the treatment period.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Nevanac with your healthcare provider.
• Do not drive or operate machinery if you experience blurred vision or other visual disturbances after using Nevanac.

Storage Instructions

• Store Nevanac ophthalmic suspension at room temperature (15°C to 25°C) in a dry place, away from moisture and heat.
• Keep the bottle tightly closed when not in use.
• Do not use Nevanac if the solution changes color or becomes cloudy.
• Keep Nevanac out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021862s017lbl.pdf