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Monopril (fosinopril)

Indications

• Monopril tablets are indicated for the treatment of high blood pressure (hypertension).
• It helps to reduce the risk of stroke, heart attack, and kidney problems by lowering blood pressure.
• Used for the management of heart failure to improve survival and reduce hospitalizations.

Dosage and Administration

• Take Monopril tablets exactly as prescribed by your doctor, usually once daily.
• Swallow the tablets whole with a full glass of water.
• Take Monopril with or without food.
• Maintain a consistent schedule to ensure the best therapeutic effect.
• Do not exceed the prescribed dose of Monopril or take it more frequently than directed by your doctor.
• Do not stop taking Monopril abruptly without consulting your doctor, as it may worsen your condition.
• Do not share your medication with others, even if they have similar symptoms.

Mechanism of Action

Monopril contains Fosinopril, an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby relaxing blood vessels, reducing blood pressure, and decreasing the workload on the heart.

Contraindications

• Do not use Monopril if you have a known allergy to Fosinopril or any other ingredients in the tablets.
• Avoid Monopril if you have a history of angioedema related to previous ACE inhibitor treatment.
• Do not use Monopril if you are pregnant or planning to become pregnant, as it can cause harm to the fetus.
• Consult your doctor before using Monopril if you have existing medical conditions, particularly kidney or liver problems, or if you are taking medications that affect potassium levels.

Side Effects

Common Side Effects:

• Cough
• Dizziness
• Headache
• Fatigue
• Nausea
• Diarrhea

Serious Side Effects:

• Severe allergic reactions (angioedema: swelling of face, lips, tongue, or throat)
• High potassium levels (hyperkalemia) leading to muscle weakness or slow/irregular heartbeat
• Kidney problems (changes in urine output, swelling in the legs or ankles)
• Liver problems (yellowing of the skin or eyes, dark urine, severe fatigue)
• Signs of infection (fever, sore throat, chills)

Precautions

• Inform your doctor about any existing medical conditions or medications you are taking before using Monopril.
• Be cautious if you have a history of kidney or liver problems, as dose adjustments may be necessary.
• Monitor your blood pressure regularly to ensure Monopril is effectively managing your condition.
• Avoid alcohol while taking Monopril, as it can further lower your blood pressure and increase the risk of side effects.

Storage Instructions

• Store Monopril tablets at room temperature (20°C to 25°C) in a dry place, away from moisture and heat.
• Keep the tablets in their original packaging until they are ready to use.
• Do not use Monopril if the tablets appear discolored, damaged, or show signs of deterioration.
• Keep Monopril out of the reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019558s060lbl.pdf