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Methazolamide (methazolamide)

Indications

• Glaucoma: You can use Methazolamide to treat certain types of glaucoma, such as chronic open-angle glaucoma or secondary glaucoma, helping to reduce intraocular pressure and prevent damage to your optic nerve.
• Acute Angle-Closure Glaucoma: Your doctor may prescribe Methazolamide to manage acute angle-closure glaucoma, aiding in the reduction of eye pressure before surgery.
• Ocular Hypertension: Methazolamide is also used to treat ocular hypertension, helping to lower high pressure within your eyes and reduce the risk of developing glaucoma.

Dosage and Administration

• Take Methazolamide exactly as prescribed by your doctor.
• Swallow the tablets whole with a full glass of water.
• Take it with food if you experience stomach upset.
• Follow your dosing schedule consistently to maintain effective pressure control in your eyes.
• Inform your doctor about any other medications or supplements you are taking.
• Do not crush, chew, or break the tablets.
• Avoid skipping doses; take it as soon as you remember if you miss a dose, but do not double dose to make up for a missed one.
• Do not stop taking Methazolamide without consulting your doctor, even if you feel better.
• Avoid alcohol as it can increase the risk of side effects.

Mechanism of Action

Methazolamide works by inhibiting the enzyme carbonic anhydrase, which is involved in the production of aqueous humor in the eye. By reducing the production of aqueous humor, methazolamide decreases intraocular pressure, helping to manage conditions like glaucoma and ocular hypertension.

Contraindications

• Do not use Methazolamide if you are allergic to methazolamide, other sulfonamides, or any of its ingredients.
• Avoid using this medication if you have severe kidney or liver disease.
• Do not take Methazolamide if you have a history of electrolyte imbalances, such as low potassium or sodium levels.
• Pregnant women should not use Methazolamide due to potential harm to the unborn baby.
• Do not use Methazolamide if you have adrenal gland failure or Addison’s disease.

Side Effects

Common Side Effects

• Nausea
• Vomiting
• Diarrhea
• Dizziness
• Fatigue

Serious Side Effects

• Severe skin reactions (rash, itching, blistering)
• Yellowing of the skin or eyes (jaundice)
• Unusual bleeding or bruising
• Signs of infection (fever, sore throat)
• Severe electrolyte imbalances (muscle cramps, irregular heartbeat)

Precautions

• Inform your doctor about any existing health conditions, especially kidney, liver, or adrenal gland problems.
• Regularly monitor your blood counts and electrolyte levels as directed by your doctor.
• Use effective contraception during treatment if you are of childbearing age and consult your doctor if you are pregnant or planning to become pregnant.
• Discuss all other medications you are taking with your doctor to avoid potential interactions.
• Stay hydrated, especially in hot weather or during exercise, to prevent dehydration.
• If you experience symptoms of severe side effects, contact your doctor immediately.

Storage Instructions

• Store Methazolamide at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the tablets in their original container, tightly closed.
• Protect from moisture and light.

References

https://www.drugs.com/pro/methazolamide.html