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Megace (megestrol acetate)

Indications

Megace tablets stimulate appetite and promote weight gain in patients with AIDS-related wasting syndrome or cancer-related cachexia.

Dosage and Administration

• Take Megace exactly as prescribed by your doctor.
• Swallow the tablets whole with water, with or without food.
• Take the medication at the same time each day for optimal effectiveness.
• Follow the prescribed dosage and duration of treatment. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your regular dosing schedule.
• Do not crush, chew, or break the tablets unless instructed by your doctor.
• Do not exceed the prescribed dosage or duration of treatment without medical advice.
• Do not use Megace to promote weight gain or appetite stimulation in individuals without AIDS-related wasting syndrome or cancer-related cachexia.
• Avoid sudden discontinuation of Megace, as it may lead to adrenal insufficiency or exacerbation of symptoms.

Mechanism of Action

Megace has a substance called megestrol acetate, which acts like a hormone in the body. It’s not entirely clear how it works to boost appetite, but it’s believed to do so by influencing certain pathways in the brain and body that control hunger and eating.

Contraindications

• Allergy to Megestrol Acetate: Do not use Megace if you have a known hypersensitivity to megestrol acetate or any of the inactive ingredients in the tablets.
• Pregnancy: Megace may cause harm to the fetus and should not be used during pregnancy unless clearly necessary. Use effective contraception during treatment.
• Thromboembolic Disorders: Use with caution in patients with a history of thromboembolic disorders, as megestrol acetate may increase the risk of blood clots.
• Undiagnosed Vaginal Bleeding: Do not use Megace in patients with undiagnosed vaginal bleeding until a diagnosis is made.

Side Effects

Common Side Effects

• Increased appetite
• Weight gain
• Fluid retention
• Nausea
• Vomiting
• Hot flashes

Serious Side Effects

• Thromboembolic events (e.g., blood clots)
• Hyperglycemia (high blood sugar)
• Hypokalemia (low potassium levels)
• Adrenal insufficiency
• Allergic reactions (rash, itching, swelling)
• Mood changes or depression

Precautions

• Inform Your Doctor About All Medications: Ensure your doctor knows about all the medications and supplements you are taking to avoid drug interactions.
• Monitor for Side Effects: Report any unusual symptoms or side effects to your doctor promptly.
• Pregnancy and Breastfeeding: Use effective contraception during treatment with Megace, and avoid breastfeeding while using the medication.
• Monitor Blood Glucose Levels: Megace may increase blood glucose levels, especially in patients with diabetes. Monitor blood sugar levels regularly.
• Bone Health: Long-term use of Megace may increase the risk of osteoporosis. Discuss bone health monitoring with your doctor.

Storage Instructions

• Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Protect from moisture and light.
• Keep in the original container tightly closed.
• Keep out of reach of children and pets.
• Do not use after the expiration date on the container.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021778s018lbl.pdf