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Medrol (methylprednisolone)

Indications

Medrol tablets are used for the following purposes:

• Anti-inflammatory: Treats inflammation associated with a variety of conditions such as allergic reactions, asthma, arthritis, and skin conditions.
• Immunosuppressant: Suppresses the immune system to prevent the body from attacking its own tissues, used in certain autoimmune diseases and organ transplants.

Dosage and Administration

• Take Medrol exactly as prescribed by your doctor.
• Swallow the tablets whole with water, with or without food.
• Take the medication at the same time(s) each day to maintain consistent levels in the body.
• Follow the prescribed dosage and duration of treatment.
• Take the missed dose as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your regular dosing schedule.
• Do not crush, chew, or break the tablets unless instructed by your doctor.
• Do not suddenly stop taking Medrol without consulting your doctor, as it may lead to withdrawal symptoms.
• Do not exceed the prescribed dosage or duration of treatment without medical advice.
• Avoid alcohol consumption while taking Medrol, as it may increase the risk of stomach irritation and other side effects.

Mechanism of Action

Medrol contains methylprednisolone, a synthetic corticosteroid that mimics the action of naturally occurring corticosteroid hormones in the body. It works by suppressing inflammation and immune responses, thereby reducing symptoms associated with various inflammatory and autoimmune conditions.

Contraindications

• Allergy to Methylprednisolone: Do not use Medrol if you have a known hypersensitivity to methylprednisolone or any of the inactive ingredients in the tablets.
• Systemic Fungal Infections: Avoid use in patients with systemic fungal infections unless specific anti-infective therapy is employed.
• Live Vaccines: Do not receive live vaccines while taking Medrol, as it may impair the immune response to the vaccine.
• Recent Myocardial Infarction: Use with caution in patients with recent heart attacks, as corticosteroids may increase the risk of heart failure.

Side Effects

Common Side Effects

• Increased appetite
• Weight gain
• Insomnia
• Fluid retention
• Mood changes (e.g., irritability)
• Increased susceptibility to infections

Serious Side Effects

• Severe allergic reactions (rash, itching, swelling)
• Mood swings or behavioral changes (e.g., depression, psychosis)
• Irregular heartbeat
• Muscle weakness or wasting
• Vision changes
• Signs of infection (fever, sore throat, persistent cough)

Precautions

• Inform Your Doctor About All Medications: Ensure your doctor knows about all the medications and supplements you are taking to avoid drug interactions.
• Monitor for Side Effects: Report any unusual symptoms or side effects to your doctor promptly.
• Pregnancy and Breastfeeding: Consult your doctor before using Medrol if you are pregnant, planning to become pregnant, or breastfeeding.
• Monitor Blood Glucose Levels: Corticosteroids may increase blood glucose levels, especially in patients with diabetes. Monitor blood sugar levels regularly.
• Bone Health: Long-term use of corticosteroids may increase the risk of osteoporosis. Discuss bone health monitoring with your doctor.

Storage Instructions

• Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Protect from moisture and light.
• Keep in the original container tightly closed.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/011153s075lbl.pdf