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Maxalt-MLT (rizatriptan benzoate)

Indications

You can use Maxalt-MLT to treat acute migraine attacks with or without aura. It helps to relieve headache pain, sensitivity to light and sound, and other migraine symptoms quickly, allowing you to return to your daily activities.

Dosage and Administration

• Take Maxalt-MLT as soon as you notice migraine symptoms for the best effect.
• Place the tablet on your tongue and allow it to dissolve completely before swallowing, with or without water.
• Follow your doctor’s instructions on the correct dosage, typically 5 mg or 10 mg, depending on your condition and response.
• If your migraine returns after relief, you can take a second dose at least 2 hours after the first. Do not exceed the maximum recommended dose of 30 mg in a 24-hour period.
• Inform your doctor about any other medications or supplements you are taking.
• Do not take Maxalt-MLT if you have used another migraine medication (such as another triptan or ergotamine) within the past 24 hours.
• Do not use Maxalt-MLT to prevent migraines; it is only for treating active migraine attacks.
• Avoid taking more than the prescribed dose to prevent severe side effects.
• Do not take Maxalt-MLT if you have phenylketonuria (PKU), as it contains phenylalanine.

Mechanism of Action

Maxalt-MLT works by stimulating serotonin (5-HT) receptors in the brain, leading to the constriction of blood vessels around the brain. This action reduces the inflammation and dilation of blood vessels that cause migraine pain and other symptoms, providing relief from acute migraine attacks.

Contraindications

• Do not use Maxalt-MLT if you are allergic to rizatriptan or any of its ingredients.
• Avoid using this medication if you have a history of heart disease, including angina, heart attack, or irregular heartbeats.
• Do not take Maxalt-MLT if you have uncontrolled high blood pressure.
• Avoid using this medication if you have a history of stroke or transient ischemic attack (TIA).
• Do not use Maxalt-MLT if you have severe liver or kidney disease without consulting your doctor.
• Pregnant women should not use Maxalt-MLT without discussing it with their doctor.

Side Effects

Common Side Effects

• Dizziness
• Drowsiness
• Fatigue
• Dry mouth
• Nausea

Serious Side Effects

• Chest pain or tightness
• Shortness of breath
• Severe abdominal pain
• Irregular or rapid heartbeat
• Signs of a severe allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing)

Precautions

• Inform your doctor about any existing health conditions, especially cardiovascular diseases, liver or kidney problems, or risk factors for heart disease.
• Regularly monitor your blood pressure if you are at risk for hypertension.
• Avoid taking Maxalt-MLT with MAO inhibitors or within 2 weeks of stopping an MAO inhibitor, as it can cause dangerous interactions.
• Use effective contraception during treatment if you are of childbearing age, and consult your doctor if you are pregnant or planning to become pregnant.

Storage Instructions

• Store Maxalt-MLT at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the tablets in their original packaging to protect them from moisture and light.
• Keep out of reach of children and pets.
• Do not use after the expiration date on the label.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020864s011s016s017s018s019,020865s012s016s018s020s021lbl.pdf