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Lialda (mesalamine)

Indications

• Lialda is used to treat mild to moderate ulcerative colitis, helping reduce inflammation in the colon.
• It is prescribed to maintain remission in patients with ulcerative colitis, preventing flare-ups.
• It can also be used for proctitis treatment, where inflammation occurs in the rectum lining.

Dosage and Administration

• Take Lialda as prescribed by your healthcare provider.
• Take the tablet whole without crushing, breaking, or chewing.
• Take Lialda with a meal to enhance absorption and reduce the risk of stomach upset.
• Take the medication at the same time each day to maintain a consistent level in your bloodstream.
• Do not skip doses, as consistent use is important for managing your condition.
• Avoid taking the tablet on an empty stomach as it may cause stomach irritation.
• Do not take antacids simultaneously as they may interfere with the absorption of the medication.

Mechanism of Action

Lialda (mesalamine) works by reducing inflammation in the colon. Mesalamine is believed to inhibit the production of substances in the lining of the colon that cause inflammation, such as prostaglandins and leukotrienes. By controlling this inflammation, Lialda helps reduce symptoms like diarrhea, rectal bleeding, and abdominal pain associated with ulcerative colitis.

Contraindications

• Allergy to Mesalamine: Do not use the medication if you have a known allergy to Mesalamine or any other ingredients in the tablet.
• Aspirin Allergy: Avoid if you are allergic to aspirin or other salicylates, as mesalamine is related to these medications.
• Severe Liver Impairment: Not recommended for patients with severe liver disease due to the potential for liver toxicity.
• Severe Kidney Impairment: Should not be used in patients with severe kidney problems as it can cause further kidney damage.
• Gastrointestinal Obstruction: Avoid it in patients with existing gastrointestinal blockages, as it may exacerbate the condition.

Side Effects

Common Side Effects:

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Vomiting
• Rash

Serious Side Effects:

• Severe abdominal pain
• Bloody diarrhea
• Chest pain
• Shortness of breath
• Severe headache or dizziness
• Unusual tiredness or weakness
• Allergic reactions such as hives, swelling, and difficulty breathing

Precautions

• Hydration: Ensure adequate fluid intake to prevent kidney stones and maintain kidney function.
• Pregnancy and Breastfeeding: Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Sun Exposure: Mesalamine can make your skin more sensitive to sunlight, so wear protective clothing and use sunscreen when outdoors.
• Other Medications: Inform your doctor about all other medications you are taking to avoid potential interactions.

Storage Instructions

• Store Lialda at room temperature between 20°C to 25°C (68°F to 77°F).
• Protect from moisture and light; do not store in the bathroom.
• Ensure the medication is stored in a safe place away from children.
• Keep the tablets in their original container until ready to use to ensure they remain effective and safe.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022000s019lbl.pdf