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Lexapro (escitalopram)

Indications

Lexapro is indicated for:

• The treatment of major depressive disorder (MDD) in adults and pediatric patients 12 years of age and older.
• The treatment of generalized anxiety disorder (GAD) in adults and pediatric patients 7 years and older.

Dosage and Administration

• Read the Medication Guide before starting Lexapro and consult your healthcare provider for guidance.
• Take Lexapro by mouth with or without food, usually once daily in the morning or evening, as directed by your healthcare provider.
• Follow your healthcare provider’s instructions carefully to reduce the risk of side effects.
• Take Lexapro regularly at the same time each day. It may take 1 to 2 weeks to feel a benefit and 4 weeks to feel the full effect.
• Report any new or worsening symptoms to your healthcare provider.
• Do not increase the dose or frequency without consulting your healthcare provider.
• Do not stop abruptly without consulting your healthcare provider.

Dosage is based on your medical condition, age, and response to treatment. Inform your healthcare provider about all medications being used.

Mechanism of Action

Lexapro works by increasing the levels of serotonin in the brain, which helps improve mood, sleep, appetite, and energy levels.

Contraindications of Lexapro

• Do not use Lexapro with or within 14 days of stopping MAOIs, linezolid, or intravenous methylene blue.
• Avoid using it with pimozide.
• Do not use if allergic to Escitalopram, Citalopram, or any inactive ingredients.

Side Effects of Lexapro

Common Side Effects:

• Gastrointestinal issues
• Headache
• Dry mouth
• Insomnia
• Nausea
• Respiratory symptoms (e.g., pharyngitis, rhinitis)

Serious Side Effects:

• Sudden changes in mood or thinking.

Sexual Side Effects:

• May occur, usually improving after the initial weeks of treatment. 

Dosage-Related Side Effects:

• At higher doses, gastrointestinal side effects such as diarrhea may occur.

Precautions

• Monitor for serotonin syndrome, discontinuation syndrome, seizures, and activation of mania/hypomania.
• Use caution if you have conditions affecting metabolism or hemodynamic responses.
• Monitor for hyponatremia, increased bleeding risk, interference with cognitive and motor performance, angle closure glaucoma, and sexual dysfunction.

Storage Instructions

Store Lexapro at room temperature between 20°C to 25°C (68°F to 77°F). 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/021323s055,021365s039lbl.pdf