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Latuda (lurasidone)

Indications

Latuda is indicated for:

• Schizophrenia: Latuda is prescribed for the treatment of schizophrenia in adults and adolescents aged 13 and older. It helps in managing symptoms such as hallucinations, delusions, and disorganized thinking.
• Bipolar Depression: Used to treat depressive episodes associated with bipolar I disorder in adults and children aged 10 and older, either alone or in combination with other medications.

Dosage and Administration

• Take Latuda exactly as prescribed by your doctor.
• Take medication with food (at least 350 calories) to enhance absorption.
• Swallow the tablet whole with water, without crushing or chewing.
• Take Latuda at the same time every day to maintain an even level of the medication in your body.
• Do not skip doses or stop taking Latuda without consulting your doctor, even if you feel better.
• Avoid consuming grapefruit or grapefruit juice while taking Latuda, as it can increase the risk of side effects.
• Do not take more than the prescribed dose; overdose can be harmful.
• Avoid operating heavy machinery or driving until you know how Latuda affects you, as it can cause drowsiness.

Mechanism of Action

Latuda is an atypical antipsychotic that works by modulating the effects of certain neurotransmitters in the brain, primarily dopamine and serotonin. By balancing these chemicals, Latuda helps to alleviate symptoms of schizophrenia and bipolar depression, improving mood, thinking, and behavior.

Contraindications

• Allergy to Lurasidone: Do not use it if you have had an allergic reaction to lurasidone or any of the ingredients in the tablet.
• Use with Strong CYP3A4 Inhibitors or Inducers: Avoid using Latuda with medications that strongly affect the CYP3A4 enzyme, as it can alter Latuda’s effectiveness and safety.
• Severe Liver or Kidney Impairment: Not recommended for patients with significant liver or kidney dysfunction.

Side Effects:

Common Side Effects

• Drowsiness
• Nausea
• Vomiting
• Indigestion
• Weight gain
• Restlessness

Serious Side Effects

• Severe allergic reactions (e.g., rash, itching, swelling)
• Tardive dyskinesia (uncontrollable movements)
• Neuroleptic malignant syndrome (severe muscle stiffness, fever, confusion)
• High blood sugar levels
• Changes in cholesterol or triglyceride levels
• Suicidal thoughts or behaviors

Precautions

• Blood Sugar Monitoring: Regularly monitor blood sugar levels if you have diabetes or are at risk of developing diabetes.
• Weight Monitoring: Monitor weight regularly, as Latuda can cause weight gain.
• Mental Health Monitoring: Be vigilant for any new or worsening symptoms of depression or suicidal thoughts.
• Orthostatic Hypotension: Be cautious of dizziness or fainting when rising too quickly from a sitting or lying position.
• Avoid Alcohol: Refrain from consuming alcohol, as it can increase the risk of side effects.

Storage Instructions

• Store Latuda at room temperature between 20°C to 25°C (68°F to 77°F).
• Keep it in the original container to protect it from light and moisture.
• Keep out of reach of children.
• Do not use after the expiration date on the label.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/200603s035lbl.pdf