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Latisse (bimatoprost)

Indications

Latisse is specifically indicated to treat hypotrichosis, a condition where eyelashes are inadequate or insufficient. It helps in increasing the length, thickness, and darkness of the eyelashes.

Dosage and Administration

• Apply Latisse once daily in the evening.
• Use the sterile applicator provided with the product.
• Place one drop of Latisse on the applicator and draw it along the skin of the upper eyelid margin at the base of the eyelashes.
• Blot any excess solution beyond the eyelid with a tissue or cotton pad.
• Ensure your face is clean and makeup-free before application.
• Do not apply Latisse to the lower eyelid.
• Avoid touching the dropper tip or applicator to prevent contamination.
• Do not use Latisse more than once a day, as increased dosage does not enhance results and may cause side effects.
• Avoid using other eye products or solutions on the treated area unless advised by your doctor.

Mechanism of Action

Latisse contains bimatoprost, a prostaglandin analog. It works by prolonging the growth phase (anagen phase) of the eyelash hair cycle. This results in longer, thicker, and darker eyelashes. Bimatoprost’s exact mechanism in promoting eyelash growth is not fully understood, but it is believed to increase the number of hairs in the growth phase and the duration of this phase.

Contraindications

• Allergy to Bimatoprost: Do not use it if you have had an allergic reaction to bimatoprost or any other ingredients in the solution.
• Eye Infections: Avoid using Latisse if you have an active eye infection or inflammation.
• Pregnancy and Breastfeeding: Not recommended for use during pregnancy or while breastfeeding unless specifically prescribed by your doctor.
• Eye Surgery: Consult your doctor if you have had recent eye surgery or have any eye conditions.

Side Effects

Common Side Effects

• Eye itching
• Redness of the eye
• Dry eyes
• Darkening of the skin around the eyes
• Irritation

Serious Side Effects

• Vision changes
• Eye pain
• Severe eye irritation
• Signs of an allergic reaction (e.g., rash, swelling, difficulty breathing)
• Increased brown pigmentation of the colored part of the eye (iris)

Precautions

• Eye Monitoring: Regular eye check-ups are advised to monitor any changes or side effects.
• Skin Pigmentation: Be aware that Latisse can cause darkening of the eyelid skin, which may be reversible.
• Iris Pigmentation: Latisse may cause permanent increased brown pigmentation of the iris.
• Contact Lens Wearers: Remove contact lenses before application and wait at least 15 minutes before reinserting them.
• Application Caution: Use a fresh, sterile applicator for each eye to avoid contamination.

Storage Instructions

• Store Latisse at room temperature between 2°C to 25°C (36°F to 77°F).
• Keep the bottle tightly closed when not in use.
• Protect from light and moisture.
• Keep out of reach of children.
• Do not freeze the solution.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022369s005lbl.pdf