Are you Looking to Buy Kombiglyze XR (Metformin/Saxagliptin) from PrescriptionPoint.

Kombiglyze XR (metformin/saxagliptin)

Indications

It is used to improve blood sugar control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise.

Ingredients

• Active Ingredients: Saxagliptin, Metformin hydrochloride
• Inactive Ingredients: Microcrystalline cellulose, Hypromellose, Magnesium stearate, Polyvinyl alcohol, Polyethylene glycol, Talc, Titanium dioxide, FD&C Blue No. 2, FD&C Red No. 40, Aluminum oxide

Dosage and Administration

• Take Kombiglyze XR tablets exactly as prescribed by your healthcare provider.
• Swallow the tablet whole; do not crush, chew, or split it.
• Take once daily with the evening meal to reduce gastrointestinal side effects.
• Follow the prescribed dosing schedule, starting with a low dose and gradually increasing as directed by your doctor.
• Monitor your blood sugar levels regularly as advised by your healthcare provider.
• Do not stop taking Kombiglyze XR without consulting your doctor.
• Avoid excessive alcohol intake while taking Kombiglyze XR, as it may increase the risk of lactic acidosis.
• Do not take Kombiglyze XR if you have a known allergy to saxagliptin, metformin, or any of the inactive ingredients.
• Avoid using Kombiglyze XR in cases of severe kidney disease or metabolic acidosis.

Mechanism of Action

Kombiglyze XR combines two antidiabetic medications: saxagliptin, a DPP-4 inhibitor, and metformin, a biguanide. Saxagliptin works by increasing the levels of incretin hormones, which help to regulate blood sugar by increasing insulin release and decreasing glucagon levels. Metformin reduces glucose production in the liver, increases insulin sensitivity, and improves glucose uptake in peripheral tissues. Together, these actions help to control blood sugar levels in patients with type 2 diabetes.

Contraindications

• Severe Kidney Disease: Do not use in patients with severe renal impairment (eGFR below 30 mL/min/1.73 m²).
• Metabolic Acidosis: Avoid use in patients with metabolic acidosis, including diabetic ketoacidosis.
• Hypersensitivity: Do not use it if you have a known allergy to saxagliptin, metformin, or any other components of the tablet.
• Lactic Acidosis: Patients with a history of lactic acidosis should not use Kombiglyze XR.

Side Effects

Common Side Effects:

• Upper respiratory tract infection
• Headache
• Diarrhea
• Nausea
• Vomiting
• Stomach pain

Serious Side Effects:

• Lactic acidosis (symptoms include muscle pain, difficulty breathing, stomach pain, dizziness, feeling cold, or tiredness)
• Severe allergic reactions (rash, itching, swelling, difficulty breathing)
• Pancreatitis (severe abdominal pain, nausea, vomiting)
• Hypoglycemia (low blood sugar, symptoms include shakiness, dizziness, sweating, hunger)
• Heart failure

Precautions

• Kidney Function: Regularly monitor kidney function, especially in patients with kidney disease.
• Lactic Acidosis Risk: Be aware of the symptoms of lactic acidosis and seek immediate medical attention if they occur.
• Heart Failure: Use with caution in patients with a history of heart failure.
• Hypoglycemia: Monitor blood sugar levels closely, especially when taken with other medications that can cause hypoglycemia.
• Medical History: Inform your doctor about any medical conditions, especially kidney disease, liver disease, heart problems, or history of pancreatitis.
• Medication Interactions: Inform your doctor about all medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements, to avoid interactions.

Storage Instructions

• Store Kombiglyze XR tablets at room temperature between 68°F to 77°F (20°C to 25°C).
• Keep the tablets in their original container, tightly closed.
• Protect from light and moisture.
• Keep out of reach of children and pets.

Why Choose Our Online Pharmacy for Kombiglyze XR?

Authenticity and Safety

Certified Authenticity: PrescriptionPoint is accredited by CIPA and IPABC, guaranteeing that every drug we offer is genuine and safe.

Prescription Requirement: We prioritize your well-being by requiring a valid prescription from a healthcare provider, ensuring that Kombiglyze xr is suitable for your condition.

Cost and Savings

Affordable Pricing: PrescriptionPoint provides some of the most competitive prices for Kombiglyze xr online, helping you reduce your drug expenses.

Generic Alternatives: Besides the brand-name Kombiglyze xr, we offer generic Saxagliptin and Metformin Extended-Release, which is just as effective and more budget friendly.

Customer Service

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How to Order Kombiglyze XR Online in Canada?

Online

You can easily buy Kombiglyze xr or its generic alternative Saxagliptin and Metformin Extended-Release on our website, www.prescriptionpoint.com.

Phone

For personalized assistance, you can place your order for Kombiglyze xr by speaking with one of our friendly customer support representatives. Just call us on +1-877-244-0431, and we will be happy to assist you.

Fax

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References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/200678s003s004lbl.pdf

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