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Jublia (efinaconazole)

Indications

Jublia is prescribed for the treatment of fungal infections of the toenails caused by dermatophytes.

Dosage and Administration

• Apply Jublia once daily to the affected toenail(s) using the built-in brush applicator.
• Ensure the toenail is clean and dry before application.
• Cover the entire toenail, including the underside of the nail tip and the skin beneath the nail.
• Allow the solution to dry completely before putting on socks or shoes.
• Use consistently at the same time each day for the full duration prescribed by your healthcare provider, usually 48 weeks.
• Do not apply it to open wounds, cuts, or broken skin.
• Avoid getting the solution in your eyes, mouth, or vagina.
• Do not use nail polish or other cosmetic nail products on treated nails.
• Do not skip applications; if you miss a dose, apply it as soon as you remember unless it is close to the time for the next dose.
• Do not use occlusive dressings unless directed by your doctor.

Mechanism of Action

Jublia is an antifungal medication that works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. This disruption in ergosterol production leads to increased membrane permeability and ultimately causes the death of the fungal cells, effectively treating the fungal infection in the toenails.

Contraindications

Jublia should not be used if:

• You are allergic to Efinaconazole or any other ingredients in Jublia.
• You have severe skin reactions such as blisters, itching, or severe redness.

Side Effects

Common Side Effects:

• Ingrown toenail
• Application site dermatitis
• Application site vesicles (blisters)
• Application site pain

Serious Side Effects:

• Severe allergic reactions (symptoms: rash, itching, swelling, severe dizziness, trouble breathing)
• Severe skin irritation (symptoms: severe redness, blistering, or peeling at the application site)

Precautions

• Discontinue use and seek medical advice if you develop severe itching, swelling, or difficulty breathing.
• Keep your feet clean and dry to support the effectiveness of the treatment.
• Do not use nail polish or undergo professional pedicures during treatment.
• Some products might interact with Jublia and affect its efficacy or increase side effects.
• Avoid exposing the treated toenail to excessive moisture or prolonged water immersion.

Storage Instructions

• Keep between 68°F to 77°F (20°C to 25°C).
• Store in a dry place away from direct heat sources.
• Ensure that children do not have access to the medication.
• Ensure the solution is stored in the original bottle with the cap tightly closed.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/203567s006lbl.pdf