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Invega (paliperidone)

Indications

Invega is indicated for-

• Schizophrenia: Used to treat symptoms of schizophrenia, including hallucinations, delusions, disorganized thinking, and emotional withdrawal.
• Bipolar Disorder: Helps manage symptoms of bipolar disorder, including manic or mixed episodes and depressive episodes, as part of a comprehensive treatment plan.

Dosage and Administration

• Take Invega exactly as prescribed by your healthcare provider.
• Take the tablet once daily, preferably at the same time each day, with or without food.
• Swallow the tablet whole with a glass of water.
• Drink plenty of fluids while taking Invega to stay hydrated.
• Do not double dose. If you miss a dose, take it as soon as you remember. If it’s close to the next dose, skip the missed dose and continue with your regular schedule.
• Avoid alcohol as it can increase the risk of side effects.
• Do not stop taking Invega suddenly without consulting your doctor, as it may cause withdrawal symptoms or a relapse of your condition.

Mechanism of Action

Invega is an antipsychotic medication that works by blocking the action of dopamine and serotonin receptors in the brain. This helps to regulate the activity of certain neurotransmitters involved in the symptoms of schizophrenia and bipolar disorder, leading to a reduction in symptoms such as hallucinations, delusions, and mood disturbances.

Contraindications

• Allergic Reactions: Do not use it if you are allergic to Paliperidone or any of the ingredients in Invega.
• Parkinson’s Disease: Contraindicated in patients with Parkinson’s disease or a history of neuroleptic malignant syndrome (NMS).
• Severe Renal Impairment: Avoid use in patients with severe renal impairment (kidney problems).
• QT Prolongation: Not recommended for patients with a history of QT prolongation or other significant heart rhythm abnormalities.
• Breastfeeding: Avoid breastfeeding while taking Invega, as it may pass into breast milk and harm the baby.

Side Effects

Common Side Effects:

• Drowsiness
• Dizziness
• Weight gain
• Constipation
• Dry mouth

Serious Side Effects:

• Extrapyramidal symptoms (muscle stiffness, tremors, restlessness)
• Tardive dyskinesia (involuntary movements)
• Neuroleptic malignant syndrome (fever, muscle stiffness, confusion)
• Hyperglycemia (high blood sugar)
• Orthostatic hypotension (low blood pressure upon standing)

Precautions

• Regular Monitoring: Undergo regular monitoring of your symptoms and overall health with your healthcare provider.
• Inform About Other Medications: Inform your doctor about all other medications you are taking, including over-the-counter drugs and supplements, to avoid interactions.
• Avoid Overheating: Avoid overheating or becoming dehydrated, as Invega can impair the body’s ability to regulate temperature.
• Avoid Sun Exposure: Use sunscreen and protective clothing when outdoors, as Invega may increase sensitivity to sunlight.
• Pregnancy: Inform your doctor if you are pregnant or planning to become pregnant, as the safety of Invega during pregnancy is not well established.
• Kidney Function: Inform your doctor if you have kidney problems, as dose adjustments may be necessary.

Storage Instructions

• Store at room temperature between 20°C to 25°C (68°F to 77°F).
• Keep in a dry place away from moisture and direct sunlight.
• Store the tablets in their original packaging to protect them from light and moisture.
• Keep out of the reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022264s023lbl.pdf