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Incruse Ellipta (umeclidinium bromide)  

Indications 

Incruse Ellipta is indicated for- 

• Chronic Obstructive Pulmonary Disease (COPD) 
• Used for the maintenance treatment of COPD, including chronic bronchitis and emphysema. 
• Helps improve breathing by relaxing the muscles around the airways, making it easier to breathe. 

Dosage and Administration 

• Use Incruse Ellipta exactly as prescribed by your healthcare provider. 
• Inhale once daily at the same time each day. 
• Follow the inhalation instructions carefully to ensure proper dosage. 
• Open the cover of the inhaler. 
• Breathe out fully away from the inhaler. 
• Place the mouthpiece between your lips and close your lips around it. 
• Take a deep, steady breath through your mouth. 
• Hold your breath for about 3-4 seconds. 
• Remove the inhaler and breathe out slowly and gently. 
• Do not use Incruse Ellipta to treat sudden breathing problems. Always keep a fast-acting inhaler (rescue inhaler) for sudden symptoms. 
• Do not use more than one inhalation per day. 
• Avoid shaking the inhaler before use. 
• Do not expose the inhaler to moisture; close the cover after each use. 

Mechanism of Action 

Incruse Ellipta is a long-acting muscarinic antagonist (LAMA). It works by blocking the action of acetylcholine on muscarinic receptors in the airway muscles. This action prevents the muscles from tightening, which helps to keep the airways open and makes breathing easier for patients with COPD. 

Contraindications 

• Allergic Reactions: Do not use it if you are allergic to Umeclidinium bromide or any of the ingredients in Incruse Ellipta. 
• Severe Hypersensitivity: Avoid use if you have had severe hypersensitivity reactions to similar medications. 
• Acute Episodes of COPD: Not intended for the relief of acute episodes of bronchospasm or COPD exacerbations. 

Side Effects 

Common Side Effects: 

• Headache 
• Cough 
• Sore throat 
• Runny or stuffy nose 
• Dry mouth 

Serious Side Effects: 

• Severe allergic reactions (rash, itching/swelling, severe dizziness, trouble breathing) 
• Urinary retention (difficulty urinating, painful urination) 
• Eye pain or discomfort 
• Blurred vision 

Precautions 

• Regular Monitoring: Regularly check your progress with your healthcare provider to ensure the medication is working effectively. 
• Inform About Other Medications: Inform your healthcare provider about all other medications you are taking, including over-the-counter drugs and supplements, to avoid interactions. 
• Glaucoma: Use with caution if you have glaucoma, as this medication may worsen the condition. 
• Prostate Problems: Use with caution if you have prostate problems or difficulty urinating. 
• Not for Sudden Symptoms: Always have a fast-acting inhaler available for sudden breathing problems. 
• Avoid Contaminants: Ensure the mouthpiece is clean and free from dust and contaminants. 

Storage Instructions 

• Store at room temperature between 20°C to 25°C (68°F to 77°F). 
• Keep in a dry place away from moisture and direct sunlight. 
• Store the inhaler in its original packaging to protect it from light and moisture. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/205382s010lbl.pdf