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Femara (letrozole)

Indications

Femara tablets are prescribed for the following conditions:

• Breast Cancer Treatment: Used after surgery in postmenopausal women with hormone receptor-positive early breast cancer.
• Breast Cancer Prevention: Reduces the risk of invasive breast cancer in postmenopausal women at increased risk of developing the disease.
• Fertility Treatment: Sometimes used off-label to induce ovulation in women with infertility issues.

Dosage and Administration

• Follow your doctor’s prescription exactly. Femara is usually taken once daily, with or without food.
• Take Femara at the same time each day to maintain an even level of medication in your body.
• Complete the prescribed course of treatment, even if you feel well, unless instructed otherwise by your doctor.
• Do not skip doses. Missing doses can reduce the effectiveness of the treatment. If you miss a dose, take it as soon as you remember.
• Do not take more than the prescribed amount of Femara.

Mechanism of Action

Femara is an aromatase inhibitor. It works by blocking the enzyme aromatase, which converts androgens (hormones produced by the adrenal glands) into estrogen. By reducing estrogen levels in postmenopausal women, Femara helps prevent the growth of hormone-sensitive breast cancer cells.

Contraindications

Femara should not be used if:

• You are allergic to Letrozole.
• You are pregnant or breastfeeding.
• You have pre-menopausal hormone levels

Side Effects

Common Side Effects:

• Hot flashes
• Fatigue
• Joint pain
• Headache
• Nausea

Serious Side Effects:

• Bone Health: Reduction in bone mineral density, leading to osteoporosis and fractures.
• Cardiovascular Issues: Increased risk of cardiovascular events such as heart attack or stroke.
• Liver Problems: Liver dysfunction, indicated by symptoms such as jaundice (yellowing of the skin or eyes) or dark urine.

Precautions

• For your bone health, regular monitoring of bone mineral density may be necessary during your treatment with Femara.
• Inform your doctor if you have any cardiovascular risk factors such as hypertension, diabetes, or a history of smoking.
• Be aware that periodic liver function tests may be required to monitor your liver health during Femara treatment.
• Provide your healthcare provider with a full list of all medications you are taking, including over-the-counter drugs and supplements.

Storage Instructions

• Keep Femara tablets at a temperature between 68°F to 77°F (20°C to 25°C).
• Store in a dry place; avoid bathrooms and kitchens where humidity is high.
• Store the tablets in their original container, tightly closed, to protect from moisture and light.
• Ensure that the medication is stored safely out of the reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/020726s014lbl.pdf