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Emend (aprepitant)

Indications 

Emend (Aprepitant) capsules are prescribed for the following conditions: 

• Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV): Used in combination with other antiemetic medications to prevent nausea and vomiting caused by highly and moderately emetogenic chemotherapy. 
• Postoperative Nausea and Vomiting (PONV): Helps prevent nausea and vomiting after surgery. 

Dosage and Administration

• Take Emend exactly as prescribed by your doctor. The typical regimen involves taking Emend before chemotherapy and for a few days following the treatment. 
• Swallow the capsules whole with a full glass of water.  
• Take the first dose (usually a higher dose) for CINV 1 hour before chemotherapy. For subsequent doses, take them in the morning on the following days. 
• Do not crush, chew, or open the capsules. 
• Do not skip doses. Stick to the prescribed schedule to ensure maximum effectiveness. If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. 
• Avoid certain foods and medications. Do not consume grapefruit or grapefruit juice, as it can interact with Emend. Inform your doctor about all medications and supplements you are taking. 
• Do not take more than the prescribed amount. Overuse can increase the risk of side effects. 

Mechanism of Action 

Emend (Aprepitant) works by blocking neurokinin-1 (NK1) receptors in the brain, which are involved in the process that triggers nausea and vomiting. By inhibiting these receptors, Emend helps prevent the vomiting reflex, especially during chemotherapy or after surgery.

Contraindications  

Emend should not be used if you: 

• Are Allergic to Aprepitant: Any known hypersensitivity to Aprepitant or any component of Emend capsules. 
• Are Taking Pimozide: Using it with Pimozide is contraindicated as it can cause serious or life-threatening interactions. 
• Have Severe Liver Disease: Consult your doctor if you have significant liver issues. 

Side Effects  

Common Side Effects: 

• Fatigue 
• Diarrhea 
• Constipation 
• Indigestion 
• Loss of appetite 
• Hiccups 

Serious Side Effects: 

• Severe Allergic Reactions: Rash, itching, swelling, severe dizziness, or trouble breathing. 
• Severe Liver Problems: Yellowing of the skin or eyes (jaundice), dark urine, severe stomach pain. 
• Severe Skin Reactions: Blistering, peeling, or intense redness. 

Precautions 

• Monitor Liver Function: If you have a history of liver problems, regular monitoring of liver function may be necessary. 
• Inform About All Medications: Emend can interact with other drugs, so provide a full list of all medications, including over-the-counter and herbal supplements, to your healthcare provider. 
• Pregnancy and Breastfeeding: Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Emend may not be recommended in these situations. 
• Avoid Driving if Drowsy: Emend can cause dizziness or drowsiness; avoid driving or operating heavy machinery if you experience these effects.

Storage Instructions 

• Keep Emend capsules at a temperature between 68°F to 77°F (20°C to 25°C). 
• Store in a dry place; avoid bathrooms and kitchens where humidity is high. 
• Store the capsules in their original container, tightly closed, to protect them from moisture and light. 

References 

https://www.drugs.com/pro/emend.html