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Differin Gel (adapalene) 

Indications 

Differin Gel is used for treating acne vulgaris. 

Dosage and Administration 

• Apply Differin Gel exactly as prescribed by your doctor. 
• Use a thin layer on the affected area once daily, preferably before bedtime. 
• Cleanse the skin gently with a mild soap or cleanser and pat dry before applying the gel. 
• Start with a small amount (pea-sized) and spread evenly across the affected area. 
• Inform your doctor about any other skin products or medications you are using to avoid potential interactions. 
• Use sunscreen and protective clothing when outdoors, as Differin Gel can make your skin more sensitive to sunlight. 
• Do not apply Differin Gel to damaged, broken, or sunburned skin as it can cause irritation. 
• Avoid contact with eyes, lips, and mouth. If accidental contact occurs, rinse thoroughly with water. 
• Do not use other acne treatments or products containing alpha hydroxy acids (AHAs), glycolic acid, or salicylic acid without consulting your doctor, as these can increase skin irritation. 
• Avoid using excessive amounts of Differin Gel, as this will not improve your acne faster but may increase irritation. 

Mechanism of Action 

Differin Gel works by affecting the growth of cells and decreasing swelling and inflammation. It is a retinoid-like compound that helps the skin renew itself. 

Contraindications 

Do not use Differin Gel if you are allergic to Adapalene or any of its ingredients. 

Side Effects 

Common Side Effects: 

• Dryness 
• Redness 
• Itching 
• Burning 
• Skin peeling 

Serious Side Effects: 

• Severe skin irritation 
• Severe allergic reactions (rash, itching, swelling) 

Precautions 

• Sun Exposure: You should avoid excessive exposure to sunlight and tanning beds.
• Skin Sensitivity: Use it with caution if you have sensitive skin.
• Use with Other Products: You should avoid using harsh skin products while using Differin Gel.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant or breastfeeding.

Storage Instructions 

• Store Differin Gel at 20°C to 25°C (68°F to 77°F). 
• Keep away from heat and direct light. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021753s004lbl.pdf