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Declomycin (demeclocycline)

Indications

• Bacterial Infections: You can use Declomycin to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, and skin infections, helping you recover from these conditions.
• Acne: Your doctor may prescribe Declomycin to help reduce and manage severe acne by inhibiting the growth of bacteria that cause acne.
• Chronic Bronchitis: This medication can help you treat chronic bronchitis by eliminating the bacteria responsible for the infection.
• Lyme Disease: You can use Declomycin to treat Lyme disease, an infection caused by tick bites, helping you recover and prevent complications.
• Certain Types of Pneumonia: Declomycin is effective against certain types of pneumonia, aiding in your faster recovery and reducing symptoms.

Dosage and Administration

• Take Declomycin exactly as prescribed by your doctor.
• Swallow the tablet with a full glass of water.
• Take it on an empty stomach, at least 1 hour before or 2 hours after meals.
• Adhere to the fully prescribed course, even if you start feeling better, to ensure the infection is fully cleared.
• Inform your doctor about any other medications or supplements you are taking.
• Do not crush, chew, or break the tablet.
• Avoid taking it with dairy products or calcium-fortified juices, as they can interfere with absorption.
• Do not lie down for at least 30 minutes after taking Declomycin.
• Avoid taking antacids, iron supplements, or multivitamins within 2 hours before or after taking Declomycin.
• Do not skip doses or stop taking the medication early without consulting your doctor.

Mechanism of Action

Declomycin works by inhibiting protein synthesis in bacteria. It binds to the 30S ribosomal subunit of the bacteria, preventing the addition of amino acids to the growing peptide chain. This action stops bacterial growth and replication, helping to eliminate the infection.

Contraindications

• Do not use Declomycin if you are allergic to demeclocycline or other tetracycline antibiotics.
• Avoid this medication if you have severe liver or kidney disease.
• Children under the age of 8 should not take Declomycin, as it can cause permanent tooth discoloration and affect bone growth.
• Pregnant women should not use Declomycin due to the risk of harm to the unborn baby.
• If you have a history of esophageal disorders, discuss this with your doctor before taking Declomycin.

Side Effects

Common Side Effects

• Nausea
• Vomiting
• Diarrhea
• Loss of appetite
• Sensitivity to sunlight

Serious Side Effects

• Severe headache or vision changes
• Severe stomach pain or cramps
• Yellowing of the skin or eyes (jaundice)
• Severe skin rash or itching
• Difficulty swallowing or painful swallowing

Precautions

• Inform your doctor about any existing health conditions, particularly liver or kidney disease.
• Use sunscreen and wear protective clothing when outdoors, as Declomycin can make your skin more sensitive to sunlight.
• Regular blood tests may be necessary to monitor your liver and kidney function while taking Declomycin.
• If you experience severe diarrhea, contact your doctor immediately, as this could be a sign of a more serious intestinal condition.
• Discuss all other medications you are taking with your doctor to avoid potential interactions.
• If you are breastfeeding, consult your doctor before taking Declomycin.

Storage Instructions

• Store Declomycin at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the tablets in their original container, tightly closed.
• Protect from moisture and light.
• Keep out of reach of children and pets.
• Do not use after the expiration date on the label.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050261s100lbl.pdf