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DDAVP (desmopressin acetate) 

Indications 

DDAVP tablets are indicated for- 

• Central Diabetes Insipidus:  
  • Used as antidiuretic replacement therapy for central diabetes insipidus. 
  • Helps manage temporary excessive urination and thirst after head trauma or pituitary region surgery. 
• Primary Nocturnal Enuresis: 
  • Management of bedwetting in children (primary nocturnal enuresis). 
  • Can be used alone or with behavioral conditioning or other non-drug therapies. 

Dosage and Administration 

• Take DDAVP tablets exactly as prescribed by your doctor. 
• Swallow the tablet whole with water. 
• Follow the dosage instructions provided by your healthcare provider. 
• Monitor urine volume and osmolality for response to treatment. 
• Do not crush, chew, or break the tablet. 
• Do not exceed the recommended dose without consulting your doctor. 
• Avoid using DDAVP if you have known hypersensitivity to desmopressin acetate or any of its components. 
• Do not use DDAVP if you have moderate to severe renal impairment or a history of hyponatremia. 

Mechanism of Action 

DDAVP works by reducing urine production and increasing water reabsorption in the kidneys, leading to decreased urination. It mimics the action of vasopressin, a hormone involved in regulating water balance in the body. 

Contraindications 

• Avoid DDAVP if you have known hypersensitivity to Desmopressin Acetate or its components. 
• Not recommended for patients with moderate to severe renal impairment or a history of hyponatremia. 

Side Effects 

Common Side Effects: 

• Headache 
• Nausea 
• Stomach pain 
• Nasal congestion (for intranasal formulations) 
• Throat irritation (for intranasal formulations) 

Serious Side Effects: 

• Severe allergic reactions (rare) 
• Anaphylaxis (rare, with intravenous and intranasal administration) 
• Slight elevation of blood pressure (for intranasal formulations and injection) 

Precautions 

• Use DDAVP cautiously if you have coronary artery disease or hypertension, as it may cause a slight increase in blood pressure. 
• If you have conditions like cystic fibrosis, heart failure, or renal disorders, you should be monitored closely for fluid and electrolyte imbalance. 
• Rare severe allergic reactions have been reported with DDAVP. Anaphylaxis is rare but possible with intravenous and intranasal administration, not with DDAVP tablets. 

Storage Instructions 

• Store DDAVP tablets at controlled room temperature, 20 to 25°C (68 to 77°F). 
• Keep away from excessive heat or light. 

References 

https://www.drugs.com/pro/ddavp-tablets.html