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Daypro (oxaprozin)

Indications

• Osteoarthritis: Daypro is used to relieve pain and inflammation caused by osteoarthritis, helping you manage symptoms and improve joint function.
• Rheumatoid Arthritis: This medication is also prescribed for reducing pain, swelling, and stiffness associated with rheumatoid arthritis, aiding in better joint movement.
• Juvenile Rheumatoid Arthritis: Daypro can be used for treating juvenile rheumatoid arthritis in children over the age of 6, helping control symptoms and improve quality of life.

Dosage and Administration

• Take Daypro exactly as prescribed by your doctor.
• Swallow the tablet whole with a full glass of water.
• Take it with food or milk to avoid stomach upset.
• Follow your dosing schedule regularly to get the most benefit from it.
• Inform your doctor if you need to take other medications, including over-the-counter drugs.
• Do not crush, chew, or break the tablet.
• Avoid taking it on an empty stomach if you have a sensitive stomach.
• Do not skip doses; take your dose as soon as you remember if you miss one, but do not double dose to make up for a missed one.
• Avoid alcohol while taking Daypro, as it can increase the risk of stomach bleeding.
• Do not take more than the prescribed dose.

Mechanism of Action

Daypro (oxaprozin) works by inhibiting the enzymes (COX-1 and COX-2) involved in the production of prostaglandins. Prostaglandins are chemicals in the body that cause inflammation, pain, and fever. By reducing the levels of prostaglandins, Daypro helps to alleviate pain, decrease inflammation, and reduce fever.

Contraindications

• If you are allergic to oxaprozin or any other NSAIDs, you should not take Daypro.
• Patients with a history of asthma attacks or severe allergic reactions after taking aspirin or other NSAIDs should avoid this medication.
• If you have a history of stomach ulcers or bleeding, Daypro is not recommended.
• Avoid Daypro if you have severe heart, liver, or kidney disease.
• Pregnant women, especially in the third trimester, should not use Daypro due to potential harm to the unborn baby.

Side Effects

Common Side Effects

• Headache
• Nausea
• Upset stomach
• Diarrhea
• Dizziness

Serious Side Effects

• Severe stomach pain or bloody stools
• Unusual weight gain or swelling
• Shortness of breath
• Severe skin reactions (rash, itching, blistering)
• Yellowing of the skin or eyes (jaundice)

Precautions

• Inform your doctor about any existing health conditions, especially heart, liver, or kidney disease.
• Regular monitoring may be needed if you have a history of gastrointestinal issues.
• Use caution if you are an elderly patient, as you may be more susceptible to side effects.
• Discuss all other medications you are taking with your doctor to avoid potential interactions.
• If you are breastfeeding, consult your doctor before taking Daypro.
• Limit your time in the sun and use sunscreen, as Daypro can make your skin more sensitive to sunlight.

Storage Instructions

• Store Daypro at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the tablets in their original container, tightly closed.
• Protect from moisture and light.
• Keep out of reach of children and pets.
• Do not use after the expiration date on the label.

References

https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2016/018841Orig1s028ltr.pdf