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Cordarone (amiodarone)

Indications

• Cordarone tablets are indicated for the treatment of life-threatening recurrent ventricular arrhythmias, such as ventricular fibrillation and ventricular tachycardia, that have not responded to other medications.
• It helps to restore normal heart rhythm and maintain a regular, steady heartbeat.

Dosage and Administration

• Take Cordarone tablets exactly as prescribed by your doctor, typically starting with a higher dose and gradually reducing it to a maintenance dose.
• Swallow the tablets whole with a full glass of water.
• Take Cordarone consistently, either with or without food, but in the same manner each time.
• Attend regular follow-up appointments with your doctor to monitor your response to the medication and adjust the dose if necessary.
• Do not exceed the prescribed dose of Cordarone or take it more frequently than directed by your doctor.
• Avoid grapefruit and grapefruit juice while taking Cordarone, as they can increase the medication levels in your blood and lead to adverse effects.
• Do not stop taking Cordarone abruptly without consulting your doctor, as it may cause your heart rhythm problems to return.
• Do not share your medication with others, even if they have similar symptoms.

Mechanism of Action

Cordarone contains Amiodarone, an antiarrhythmic medication that works by prolonging phase 3 of the cardiac action potential. This action helps to stabilize the heart rhythm by decreasing abnormal electrical signals in the heart, thus preventing arrhythmias.

Contraindications

• Do not use Cordarone if you have a known allergy to Amiodarone or any other ingredients in the tablets.
• Avoid Cordarone if you have severe sinus-node dysfunction, severe bradycardia, second- or third-degree atrioventricular block, or cardiogenic shock.
• Consult your doctor before using Cordarone if you have existing medical conditions, particularly thyroid disorders, liver disease, or lung disease.

Side Effects

Common Side Effects:

• Nausea
• Vomiting
• Fatigue
• Tremor
• Dizziness
• Constipation

Serious Side Effects:

• Lung toxicity (difficulty breathing, cough, chest pain)
• Liver problems (yellowing of the skin or eyes, dark urine, severe fatigue)
• Vision changes (blurred vision, seeing halos around lights)
• Thyroid problems (weight changes, intolerance to heat or cold, hair loss)
• Severe skin reactions (rash, blistering, peeling)

Precautions

• Inform your doctor about any existing medical conditions or medications you are taking before using Cordarone.
• Be cautious if you have a history of thyroid problems, as Cordarone can affect thyroid function.
• Monitor for signs of lung toxicity, such as difficulty breathing or persistent cough, and report these symptoms to your doctor immediately.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Cordarone with your healthcare provider.

Storage Instructions

• Store Cordarone tablets at room temperature (20°C to 25°C) in a dry place, away from moisture and heat.
• Keep the tablets in their original packaging until ready to use.
• Do not use Cordarone if the tablets appear discolored, damaged, or show signs of deterioration.
• Dispose of any unused or expired medication properly, following local regulations or guidelines.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/018972s054lbl.pdf