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Colcrys (colchicine)

Indications

• Colcrys tablets are indicated for the treatment and prevention of gout flares in adults.
• It is also used for the treatment of Familial Mediterranean Fever (FMF) in adults and children aged 4 years and older.

Dosage and Administration

• Take Colcrys tablets exactly as prescribed by your doctor, typically once or twice daily.
• Swallow the tablets whole with a full glass of water. The scored tablets can be split if your doctor has instructed a lower dose.
• Take Colcrys with or without food, but taking it with food can help reduce stomach upset.
• Follow your doctor’s instructions regarding the duration of use and dosing schedule.
• Take the missed dose as soon as you remember unless it is almost time for the next dose. In that case, skip the missed dose and resume your regular dosing schedule.
• Do not exceed the prescribed dose of Colcrys or take it more frequently than directed by your doctor.
• Avoid consuming grapefruit or grapefruit juice while taking Colcrys, as it can increase the medication’s levels in your blood.
• Do not stop taking Colcrys abruptly without consulting your doctor, as it may worsen your condition.

Mechanism of Action

Colcrys contains Colchicine, which works by reducing inflammation and decreasing the build-up of uric acid crystals that cause pain in gout and inflammation in FMF.

Contraindications

• Do not use Colcrys if you have a known allergy to colchicine or any other ingredients in the tablets.
• Avoid Colcrys if you have severe renal (kidney) or hepatic (liver) impairment.
• Consult your doctor before using Colcrys if you have existing medical conditions, especially kidney or liver disease, or if you are taking other medications.

Side Effects

Common Side Effects:

• Nausea or vomiting
• Diarrhea
• Stomach pain
• Headache

Serious Side Effects:

• Severe muscle pain or weakness
• Numbness or tingling in fingers or toes
• Pale or gray color of lips, tongue, or palms
• Severe diarrhea or vomiting
• Unusual bleeding or bruising

Precautions

• Inform your doctor about any existing medical conditions or medications you are taking before using Colcrys.
• Be cautious when driving or operating machinery until you know how Colcrys affects you, as it may cause dizziness or drowsiness.
• Monitor for signs of muscle weakness or unusual bleeding and report these symptoms to your doctor immediately.
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Colcrys with your healthcare provider.

Storage Instructions

• Store Colcrys tablets at room temperature (20°C to 25°C) in a dry place, away from moisture and heat.
• Keep the tablets in their original packaging until they are ready to use.
• Do not use Colcrys if the tablets appear discolored, damaged, or show signs of deterioration.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022352s017lbl.pdf