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Colazal (balsalazide disodium)

Indications

• Colazal capsules are prescribed to you for the treatment of mild to moderate active ulcerative colitis, a chronic inflammatory bowel disease characterized by inflammation and ulcers in the colon and rectum.
• It helps reduce symptoms such as diarrhea, rectal bleeding, and abdominal pain associated with ulcerative colitis flare-ups.

Dosage and Administration

• Take Colazal capsules orally with or without food as directed by your healthcare provider.
• Swallow the capsules whole with a full glass of water to prevent stomach upset.
• Do not crush, chew, or break the capsules before swallowing.
• Avoid taking antacids within 1 hour before or after taking Colazal, as they may interfere with the absorption of the medication.

Mechanism of Action

Colazal capsules contain balsalazide disodium, which is metabolized in the colon into mesalamine, an anti-inflammatory agent. Mesalamine works by reducing inflammation in the colon and rectum, thereby improving symptoms of ulcerative colitis.

Contraindications

• Do not use Colazal capsules if you are allergic to balsalazide disodium or any other ingredients in the capsules.
• Avoid using this medication if you have a history of allergic reactions to salicylates (e.g., aspirin).
• Inform your doctor about any kidney or liver problems you have before starting treatment with Colazal capsules.

Side Effects

Common side effects

• Headache
• Nausea or vomiting
• Diarrhea
• Abdominal pain or cramps
• Joint pain

Serious side effects

• Severe allergic reactions such as rash, itching, swelling, or difficulty breathing
• Worsening of ulcerative colitis symptoms or development of new symptoms
• Liver problems such as jaundice or elevated liver enzymes

Precautions

• Before using Colazal capsules, inform your healthcare provider about any other medications you are taking, especially other anti-inflammatory drugs or blood thinners.
• Attend regular follow-up appointments with your doctor to monitor your response to treatment and assess any potential side effects.
• Do not abruptly stop taking Colazal capsules without consulting your doctor, as it may lead to worsening of ulcerative colitis symptoms.

Storage Instructions

• Store Colazal capsules at room temperature away from heat and moisture.
• Keep the capsules in their original container and out of reach of children.
• Do not store Colazal in the bathroom.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020610s023lbl.pdf