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Clobex Spray (clobetasol propionate)

Indications

Clobex Spray is prescribed for the treatment of moderate to severe plaque psoriasis in adults. It helps reduce inflammation, itching, and redness associated with psoriasis.

Ingredients

• Active Ingredient: Clobetasol Propionate
• Inactive Ingredients: Ethanol, isopropyl myristate, and purified water.

Dosage and Administration

• Follow the prescription: Use Clobex Spray exactly as prescribed by your healthcare provider.
• Clean and dry skin: Ensure the affected area is clean and dry before applying the spray.
• Apply a thin layer: Spray a small amount onto the affected area and gently rub it in.
• Use twice daily: Apply the spray twice daily, in the morning and at night, unless directed otherwise by your doctor.
• Limit to affected areas: Only apply to the areas affected by psoriasis.
• Do not cover with bandages: Avoid covering the treated area with bandages or dressings unless directed by your doctor.
• Avoid contact with eyes: Keep the spray away from your eyes, mouth, and other mucous membranes.
• Do not use on face or groin: Avoid using Clobex Spray on sensitive areas such as the face, groin, or underarms.
• Do not use for extended periods: Do not use the spray for longer than prescribed, typically no more than 4 weeks.

Mechanism of Action

Clobetasol propionate is a potent topical corticosteroid that works by reducing inflammation and suppressing the immune response in the skin. It decreases the release of inflammatory substances and helps relieve symptoms such as redness, itching, and swelling associated with plaque psoriasis.

Contraindications

• Allergy to clobetasol: Do not use if you are allergic to clobetasol or any other ingredients in Clobex Spray.
• Skin infections: Avoid if you have untreated bacterial, fungal, or viral skin infections.
• Rosacea and acne: Do not use on skin conditions like rosacea or acne.

Side Effects

Common Side Effects

• Burning or stinging sensation
• Dry or cracking skin
• Itching or redness
• Skin thinning
• Stretch marks

Serious Side Effects

• Severe allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)
• Signs of skin infection (redness, swelling, oozing)
• Hypothalamic-pituitary-adrenal (HPA) axis suppression (fatigue, weakness, weight loss)
• Increased blood sugar levels
• Vision problems

Precautions

• Medical history: Inform your doctor of your complete medical history, especially if you have diabetes, immune system disorders, or skin infections.
• Monitor for side effects: Be aware of potential side effects and seek medical attention if serious symptoms occur.
• Avoid prolonged use: Prolonged use of topical steroids can cause skin thinning and other side effects; use only as directed.
• Pregnancy and breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Avoid sun exposure: Minimize exposure to sunlight or tanning beds, as the treated areas may be more sensitive to the sun.

Storage Instructions

• Store at room temperature: Keep Clobex Spray at a controlled room temperature, between 20°C to 25°C (68°F to 77°F).
• Avoid moisture and light: Store in a dry place away from light and moisture.
• Keep out of reach of children: Ensure that the medication is stored safely out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021835s015lbl.pdf