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Caduet (amlodipine and atorvastatin)

Indications

• Caduet tablets are a combination medication indicated for the treatment of hypertension (high blood pressure) and dyslipidemia (high cholesterol).
• It helps to lower blood pressure and reduce cholesterol levels in the blood, thereby reducing the risk of cardiovascular events such as heart attacks and strokes.

Dosage and Administration

• Take Caduet tablets exactly as prescribed by your doctor, usually once daily with or without food.
• Swallow the tablets whole with a full glass of water.
• Follow a consistent schedule for taking Caduet to maintain steady control of your blood pressure and cholesterol levels.
• Continue taking Caduet regularly, even if you feel well, unless instructed otherwise by your healthcare provider.
• Do not exceed the prescribed dose of Caduet or take it more frequently than directed by your doctor.
• Do not crush, chew, or break the tablets.
• Avoid sudden discontinuation of Caduet without consulting your doctor, as it may lead to rebound hypertension or worsening of lipid levels.

Mechanism of Action

Caduet combines two active ingredients: Amlodipine, a calcium channel blocker, and Atorvastatin, a statin medication. Amlodipine works by relaxing the blood vessels, thereby lowering blood pressure, while atorvastatin reduces cholesterol production in the liver, leading to decreased levels of LDL (bad) cholesterol and triglycerides.

Contraindications

• Do not use Caduet if you have a known allergy to Amlodipine, Atorvastatin, or any other ingredients in the tablets.
• Avoid Caduet if you have severe liver disease or unexplained persistent elevations in liver enzymes.
• Consult your doctor before using Caduet if you are pregnant, planning to become pregnant, or breastfeeding.

Side Effects

Common Side Effects:

• Headache
• Swelling of the ankles or feet
• Dizziness or lightheadedness
• Muscle pain or weakness
• Abdominal pain or discomfort

Serious Side Effects:

• Liver problems (yellowing of the skin or eyes, dark urine, abdominal pain)
• Rhabdomyolysis (muscle breakdown)
• Allergic reactions (rash, itching, swelling, difficulty breathing)
• Unexplained muscle pain, tenderness, or weakness

Precautions

• Inform your doctor about any existing medical conditions, especially liver or kidney disease, before starting treatment with Caduet.
• Be cautious when driving or operating machinery until you know how the medication affects you, as it may cause dizziness or drowsiness.
• Monitor for signs of liver dysfunction or muscle problems while taking Caduet, and report any unusual symptoms to your doctor.

Storage Instructions

• Store Caduet tablets at room temperature (20°C to 25°C) in a dry place, away from moisture and heat.
• Keep the tablets in their original blister packaging until ready to use.
• Do not use Caduet if the tablets appear discolored, damaged, or show signs of deterioration.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021540s019lbl.pdf