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Axert (almotriptan)

Indications

• Axert is used to treat acute migraine headaches with or without aura.
• It helps to relieve headaches, pain, and other migraine symptoms such as nausea, vomiting, and sensitivity to light/sound.

Dosage and Administration

• Take Axert as prescribed by your doctor, usually at the first sign of a migraine.
• Swallow the tablet whole with a glass of water.
• If your symptoms improve but return after 2 hours, you may take a second dose.
• Do not take more than 25 mg (two 12.5 mg tablets) within a 24-hour period.
• Avoid taking Axert if you have taken another migraine medication (like another triptan or ergotamine) within the past 24 hours.
• Avoid taking more than the recommended dose as it can lead to serious side effects.

Mechanism of Action

Axert contains almotriptan, a selective serotonin receptor agonist (triptan). It works by narrowing blood vessels around the brain and reducing substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.

Contraindications

• Do not use Axert if you are allergic to almotriptan or any of its ingredients.
• Avoid using Axert if you have a history of heart disease, angina, or previous heart attacks.
• Do not take Axert if you have uncontrolled high blood pressure.
• Avoid using Axert if you have had a stroke or transient ischemic attack (TIA).
• Do not take Axert if you have hemiplegic or basilar migraine.

Side Effects

Common Side Effects

• Nausea
• Dry mouth
• Dizziness
• Fatigue
• Headache (other than migraine)

Serious Side Effects

• Severe allergic reactions, including rash, itching, swelling, severe dizziness, and trouble breathing
• Chest pain or tightness
• Shortness of breath
• Irregular heartbeat
• Severe stomach pain

Precautions

• Inform your doctor about your complete medical history, especially if you have cardiovascular disease, high blood pressure, liver disease, or a history of stroke.
• Notify your doctor if you experience frequent or severe headaches, as you may need a different treatment plan.
• Use caution if you are elderly, as you may be more sensitive to the side effects, particularly heart-related issues.
• Avoid driving or operating machinery until you know how Axert affects you, as it can cause dizziness or drowsiness.
• Monitor your symptoms and report any changes or worsening to your doctor immediately.

Storage Instructions

• Store Axert at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the tablets in their original container, tightly closed.
• Store Axert out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021001s015lbl.pdf