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Avodart (dutasteride)

Indications

Used to treat symptoms of an enlarged prostate (benign prostatic hyperplasia) in men. It helps improve urinary flow and may reduce the need for prostate surgery.

Dosage and Administration

• Take one capsule daily, with or without food, preferably at the same time each day.
• Swallow the capsule whole with water.
• Take a missed dose as soon as possible unless it is almost time for the next dose.
• Adhere to the dosing schedule provided by your healthcare provider.
• Do not chew, crush, or open the capsule as it can cause irritation to the mouth and throat.
• Do not double a dose if a dose is missed.
• Avoid donating blood during treatment and for at least 6 months after stopping the medication to prevent exposure to pregnant women.

Mechanism of Action

Avodart (dutasteride) works by inhibiting the conversion of testosterone to dihydrotestosterone (DHT), a hormone involved in prostate growth. By lowering DHT levels, Avodart helps shrink the prostate and relieve symptoms of BPH.

Contraindications

• Allergy to Dutasteride: Do not use the medication if you are allergic to Dutasteride or any components of Avodart.
• Pregnancy: Not for use in women, especially during pregnancy, as it can cause harm to a male fetus.
• Severe Liver Disease: Caution advised in patients with severe liver impairment.

Side Effects

Common Side Effects:

• Decreased libido (sex drive)
• Erectile dysfunction
• Ejaculation disorders
• Breast tenderness or enlargement

Serious Side Effects:

• Severe allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)
• High-grade prostate cancer (rare)
• Depressed mood

Precautions

• Prostate Cancer Screening: Regular screening for prostate cancer is recommended, as dutasteride can affect PSA test results.
• Liver Function: Regular liver function tests are recommended.
• Long-Term Use: Discuss long-term use risks and benefits with your doctor.
• Women and Children: Avoid contact with leaking capsules, especially by women who are or may become pregnant and children.

Storage Instructions

• Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Store in a dry place, away from moisture and heat.
• Keep the capsules in their original container, tightly closed.
• Keep out of reach of children to prevent accidental ingestion.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021319s032lbl.pdf