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Aromasin (exemestane)

Indications

• Used in postmenopausal women to treat hormone receptor-positive early breast cancer after 2-3 years of tamoxifen therapy.
• Treats advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.

Dosage and Administration

• Take one tablet daily after a meal, preferably at the same time each day.
• Swallow the tablet whole with water.
• Take the missed dose as soon as possible unless it is almost time for the next dose.
• Adhere to the dosing schedule provided by your healthcare provider.
• Do not chew, crush, or split the tablet.
• Do not double the dose.
• Avoid taking the medication with estrogen-containing therapies, as they can reduce the effectiveness of Aromasin.

Mechanism of Action

Aromasin (exemestane) is an aromatase inhibitor that works by decreasing estrogen production in the body. By lowering estrogen levels, it helps slow or stop the growth of hormone receptor-positive breast cancer cells.

Contraindications

• Allergy to Exemestane: Do not use the medication if you are allergic to Exemestane or any ingredients in Aromasin.
• Premenopausal Women: Not indicated for use in women who have not gone through menopause.
• Pregnancy: Not for use during pregnancy due to potential harm to the fetus.
• Breastfeeding: Do not use it while breastfeeding as it may affect the baby.
• Severe Liver or kidney disease: Caution is advised in patients with severe liver or kidney impairment.

Side Effects

Common Side Effects:

• Hot flashes
• Fatigue
• Joint pain
• Headache
• Insomnia
• Increased sweating
• Nausea

Serious Side Effects:

• Severe bone pain or fractures
• Depression
• Liver issues (yellowing of the skin or eyes, dark urine)
• Severe allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)
• Chest pain or shortness of breath

Precautions

• Bone Health: Regular bone density monitoring as Aromasin can cause bone thinning or osteoporosis.
• Cholesterol Levels: Monitor cholesterol levels as Aromasin can increase cholesterol.
• Heart Health: Monitor heart function, especially in patients with pre-existing heart conditions.
• Renal Function: Caution in patients with moderate to severe kidney impairment.
• Driving and Operating Machinery: Be cautious as the medication may cause dizziness or fatigue.

Storage Instructions

• Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Store in a dry place, away from moisture and heat.
• Keep the tablets in their original container, tightly closed.
• Keep out of reach of children to prevent accidental ingestion.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020753s020lbl.pdf