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Apriso (mesalamine)

Indications

• Apriso is used to treat ulcerative colitis, an inflammatory bowel disease.
• It helps to maintain remission in patients with ulcerative colitis.
• Apriso reduces symptoms such as diarrhea, rectal bleeding, and stomach pain.

Dosage and Administration

• Take Apriso exactly as prescribed by your doctor, usually once daily in the morning.
• Swallow the capsules whole with or without food.
• Drink a full glass of water with each dose.
• Follow your doctor’s instructions regarding diet and lifestyle changes.
• Inform your doctor about all other medications you are taking to avoid potential interactions.
• Do not crush, chew, or break the capsules.
• Avoid taking antacids simultaneously with Apriso, as they can affect the release mechanism of the medication.
• Do not stop taking Apriso suddenly without consulting your doctor.
• Avoid using Apriso if you have a known allergy to mesalamine or any of its ingredients.
• Do not share your medication with others, even if they have similar symptoms.

Mechanism of Action

Apriso contains Mesalamine, an anti-inflammatory agent. It works by inhibiting the production of certain chemicals in the lining of the colon that cause inflammation. This helps to reduce the inflammation, tissue damage, and diarrhea associated with ulcerative colitis, promoting healing and maintaining remission.

Contraindications

• Do not use Apriso if you are allergic to Mesalamine, salicylates (such as aspirin), or any of its ingredients.
• Avoid using the medication if you have severe liver or kidney disease without consulting your doctor.
• Do not take Apriso if you have a blockage in your digestive tract.

Side Effects

Common Side Effects:

• Headache
• Nausea
• Diarrhea
• Stomach pain
• Dizziness

Serious Side Effects:

• Severe allergic reactions, including rash, itching, swelling, severe dizziness, and trouble breathing
• Severe stomach pain or cramping
• Bloody diarrhea
• Chest pain or shortness of breath
• Signs of liver problems, such as yellowing of the skin or eyes, dark urine

Precautions

• Inform your doctor about all other medications you are using, including over-the-counter products and supplements.
• Notify your doctor if you have a history of liver disease, kidney disease, or heart problems.
• Use caution if you are pregnant, planning to become pregnant, or breastfeeding, and discuss the risks and benefits with your doctor.
• Stay hydrated, especially if you experience diarrhea while taking Apriso.
• Monitor your condition regularly and report any worsening symptoms to your doctor.
• If you experience severe side effects or signs of an allergic reaction, seek medical attention immediately.

Storage Instructions

• Store Apriso at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the capsules in their original container, tightly closed.
• Store Apriso out of reach of children and pets.
• Protect the capsules from moisture and light.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022301s015lbl.pdf