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Ampyra (dalfampridine)

Indications

• Used to improve walking in adults with multiple sclerosis (MS).
• It helps increase walking speed by enhancing nerve signal conduction.
• It can be beneficial for MS patients experiencing difficulty in walking or mobility.

Dosage and Administration

• Take Ampyra exactly as prescribed by your healthcare provider.
• Swallow the tablet whole with or without food.
• Take one tablet every 12 hours for optimal effect.
• Follow the prescribed dosing schedule strictly to maintain consistent blood levels of the medication.
• Store the medication at room temperature away from moisture and heat.
• Do not crush, chew, or split the tablets; this can release the drug too quickly and increase the risk of side effects.
• Do not take more than the prescribed dose as it can increase the risk of seizures.
• Avoid taking a missed dose if it is almost time for your next dose; just skip the missed dose.
• Do not use Ampyra if you have a history of seizures or moderate to severe kidney disease.
• Do not stop taking Ampyra abruptly without consulting your healthcare provider.

Mechanism of Action

Ampyra works by blocking potassium channels on nerve cells, which helps to improve the conduction of nerve signals in patients with multiple sclerosis (MS). This action can enhance walking speed and mobility in MS patients by improving the ability of damaged nerves to transmit signals.

Contraindications

• Do not use it if you are allergic to Dalfampridine or any other ingredients in Ampyra.
• Avoid use if you have a history of seizures or epilepsy.
• Not recommended if you have moderate to severe kidney disease, as this can increase the risk of side effects.
• Do not take it if you have a history of hypersensitivity reactions to Dalfampridine.

Side Effects

Common Side Effects

• Urinary tract infections
• Insomnia
• Dizziness
• Headache
• Nausea

Serious Side Effects

• Seizures
• Severe allergic reactions (e.g., rash, itching, swelling, severe dizziness, trouble breathing)
• Balance problems
• Severe or persistent urinary tract infections
• Unusual weakness or tiredness

Precautions

• Inform your doctor of your full medical history, especially if you have a history of kidney disease or seizures.
• Tell your doctor about all other medications you are taking to avoid potential interactions.
• Do not take Ampyra if you are pregnant or breastfeeding without consulting your doctor.
• Monitor for signs of urinary tract infections and report any symptoms to your healthcare provider.
• Avoid alcohol consumption as it can increase the risk of seizures.
• Ensure you have regular check-ups to monitor kidney function and overall health while on Ampyra.

Storage Instructions

• Store at room temperature between 68°F and 77°F (20°C and 25°C).
• Keep away from moisture and heat.
• Store in a safe place out of the reach of children.
• Keep the tablets in their original packaging until use.
• Do not use past the expiration date on the packaging.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/022250s018lbl.pdf