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Aldara (imiquimod) 

Indications 

• Aldara Cream is used to treat actinic keratosis (AK) on the face or scalp. 
• It is effective in treating superficial basal cell carcinoma (sBCC) in patients who cannot undergo surgery. 
• Aldara Cream is also prescribed for the treatment of external genital and perianal warts (condyloma acuminata) in patients aged 12 years and older. 

Dosage and Administration 

• Use Aldara Cream exactly as prescribed by your doctor, typically once daily before bedtime. 
• Apply a thin layer of the cream to the affected area and rub it gently. 
• Wash your hands before and after applying the cream. 
• Leave the cream on the skin for about 8 hours before washing the area with mild soap and water. 
• Follow the treatment schedule provided by your doctor, which may vary based on the condition being treated. 
• Do not apply more cream than prescribed. 
• Avoid applying Aldara Cream to broken, wounded, or irritated skin. 
• Do not use Aldara Cream in or near the eyes, lips, or nostrils. 
• Avoid sexual contact while the cream is on your skin if treating genital warts. 
• Do not cover the treated area with bandages or dressings unless instructed by your doctor. 

Mechanism of Action 

Aldara Cream contains Imiquimod, which is an immune response modifier. It works by stimulating the body’s immune system to produce interferon and other cytokines. This immune response helps to fight abnormal skin cells or viral infections, leading to the reduction and eventual elimination of actinic keratosis, basal cell carcinoma, or genital warts. 

Contraindications 

• Do not use the cream if you are allergic to Imiquimod or any of its ingredients. 
• Avoid using Aldara Cream if you have severe inflammatory skin conditions in the treatment area. 
• Do not use Aldara Cream if you have an immune system disorder without consulting your doctor. 

Side Effects 

Common Side Effects: 

• Redness 
• Swelling 
• Itching 
• Burning sensation 
• Flaking or scaling of the skin 

Serious Side Effects: 

• Severe skin reactions, including blistering, ulceration, or intense redness 
• Flu-like symptoms, such as fever, chills, fatigue, and muscle aches 
• Swollen lymph nodes 
• Severe allergic reactions, including rash, itching, swelling, severe dizziness, and trouble breathing 

Precautions 

• Inform your doctor about all other medications you are using, including over-the-counter products and supplements. 
• Notify your doctor if you have a history of autoimmune disorders or immune system problems. 
• Use caution if you are pregnant, planning to become pregnant, or breastfeeding, and discuss the risks and benefits with your doctor. 
• Avoid excessive sun exposure and use sunscreen and protective clothing when outdoors, as Aldara Cream can make your skin more sensitive to sunlight. 
• Monitor the treated area regularly and report any severe skin reactions or changes to your doctor. 

Storage Instructions 

• Store Aldara Cream at room temperature, between 20°C to 25°C (68°F to 77°F). 
• Keep the cream in its original packet until ready to use. 
• Store Aldara Cream out of reach of children and pets. 
• Protect the cream from moisture and light. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020723s022lbl.pdf