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Aldactazide (spironolactone and hydrochlorothiazide)

Indications

• Aldactazide is used to treat high blood pressure (hypertension).
• It helps reduce fluid retention (edema) in patients with conditions such as congestive heart failure, liver cirrhosis, or nephrotic syndrome.
• Aldactazide is also prescribed for patients with primary hyperaldosteronism, a condition where the body produces too much aldosterone.

Dosage and Administration

• Take Aldactazide exactly as prescribed by your doctor, typically once or twice daily.
• Take the tablets with or without food, but consistently the same way each day.
• Drink plenty of fluids unless otherwise directed by your doctor.
• Have regular blood tests to monitor your kidney function and electrolyte levels.
• Inform your doctor about all other medications you are taking to avoid potential interactions.
• Do not take more than the prescribed dose.
• Avoid consuming potassium supplements or potassium-rich foods without consulting your doctor, as Aldactazide can increase potassium levels.
• Do not skip doses or stop taking Aldactazide without consulting your doctor.
• Avoid alcohol as it can increase certain side effects of Aldactazide.

Mechanism of Action

Aldactazide combines two medications: Spironolactone and Hydrochlorothiazide. Spironolactone is an aldosterone antagonist that helps the body eliminate excess sodium and water while retaining potassium. Hydrochlorothiazide is a thiazide diuretic that helps prevent the body from absorbing too much salt, which can cause fluid retention. Together, these actions help to lower blood pressure and reduce fluid buildup in the body.

Contraindications

• Do not use Aldactazide if you are allergic to Spironolactone, Hydrochlorothiazide, or any of its ingredients.
• Avoid the medication if you have anuria (inability to produce urine), significant kidney impairment, or Addison’s disease.
• Do not take Aldactazide if you have hyperkalemia (high potassium levels) or severe liver disease.

Side Effects

Common Side Effects:

• Dizziness
• Headache
• Nausea
• Vomiting
• Diarrhea
• Abdominal pain

Serious Side Effects:

• Severe allergic reactions, including rash, itching, swelling, severe dizziness, and trouble breathing
• Signs of electrolyte imbalance, such as muscle cramps, weakness, or irregular heartbeat
• Unusual tiredness or weakness
• Severe dehydration
• Signs of liver problems, such as yellowing of the skin or eyes, dark urine
• Severe skin reactions

Precautions

• Inform your doctor about all other medications you are taking, including over-the-counter drugs and supplements.
• Notify your doctor if you have a history of kidney disease, liver disease, diabetes, or gout.
• Report any signs of electrolyte imbalance, such as muscle cramps or irregular heartbeat, to your doctor.
• Use effective contraception if you have childbearing potential and discuss the risks if you are pregnant or planning to become pregnant.
• Monitor your blood pressure regularly and keep a record of your readings.

Storage Instructions

• Store Aldactazide at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the tablets in their original container, tightly closed.
• Store Aldactazide out of reach of children and pets.
• Protect the tablets from moisture and light.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/012616s076lbl.pdf